List of highways numbered 221

The following highways are numbered 221:

Canada

 * Manitoba secondary 221.svg Manitoba Provincial Road 221
 * NL Route 221.svg Newfoundland and Labrador Route 221
 * Nova Scotia Route 221.svg Nova Scotia Route 221
 * PEI Highway 221.svg Prince Edward Island Route 221
 * Qc221.svg Quebec Route 221
 * Saskatchewan Highway 221 (jct).svg Saskatchewan Highway 221

China

 * Kokudou 221(China).svg China National Highway 221

Costa Rica

 * CR RNS 221.svg National Route 221

Japan

 * Japanese National Route Sign 0221.svg Japan National Route 221

United States

 * US 221.svg U.S. Route 221
 * Alabama 221.svg Alabama State Route 221
 * Arkansas 221.svg Arkansas Highway 221
 * California 221.svg California State Route 221
 * Florida 221.svg Florida State Road 221 (former)
 * Georgia 221.svg Georgia State Route 221 (former)
 * Iowa 221.svg Iowa Highway 221 (former)
 * K-221.svg K-221 (Kansas highway) (former)
 * Elongated circle 221.svg Kentucky Route 221
 * MA Route 221.svg Maine State Route 221
 * MN-221.svg Minnesota State Highway 221 (former)
 * MT-sec-221.svg Montana Secondary Highway 221
 * Nevada 221.svg Nevada State Route 221
 * New Mexico 221.svg New Mexico State Road 221
 * NY-221.svg New York State Route 221
 * OH-221.svg Ohio State Route 221
 * OR 221.svg Oregon Route 221
 * PA-221.svg Pennsylvania Route 221
 * Secondary Tennessee 221.svg Tennessee State Route 221
 * Texas 221.svg Texas State Highway 221 (former)
 * Texas Loop 221.svg Texas State Highway Loop 221 (former)
 * Utah SR 221.svg Utah State Route 221 (former)
 * WA-221.svg Washington State Route 221
 * WY-221.svg Wyoming Highway 221