List of highways numbered 280

Route 280, or Highway 280, may refer to:

Australia

 * McIvor Highway

Canada

 * Manitoba secondary 280.svg Manitoba Provincial Road 280
 * NB 280.svg New Brunswick Route 280

Japan

 * Japanese National Route Sign 0280.svg Japan National Route 280

United States

 * I-280.svg Interstate 280 (multiple highways)
 * US 280.svg U.S. Route 280
 * Arizona 280.svg Arizona State Route 280 (former)
 * Arkansas 280.svg Arkansas Highway 280
 * Arkansas 280S.svg Arkansas Highway 280 Spur
 * Florida 280.svg Florida State Road 280 (former)
 * Georgia 280.svg Georgia State Route 280
 * Elongated circle 280.svg Kentucky Route 280
 * MD Route 280.svg Maryland Route 280 (former)
 * MN-280.svg Minnesota State Highway 280
 * MT-sec-280.svg Montana Secondary Highway 280
 * NY-280.svg New York State Route 280
 * NC 280.svg North Carolina Highway 280
 * PA-280.svg Pennsylvania Route 280 (former)
 * South Carolina 280.svg South Carolina Highway 280
 * Secondary Tennessee 280.svg Tennessee State Route 280
 * Texas 280.svg Texas State Highway 280 (former proposed)
 * Texas Spur 280.svg Texas State Highway Spur 280
 * Texas FM 280.svg Farm to Market Road 280 (Texas)
 * Utah SR 280.svg Utah State Route 280