List of highways numbered 281

The following highways are numbered 281:

Canada

 * Qc281.svg Quebec Route 281

Japan

 * Japanese National Route Sign 0281.svg Japan National Route 281

United States

 * US 281.svg U.S. Route 281
 * Alabama 281.svg Alabama State Route 281
 * Arkansas 281.svg Arkansas Highway 281
 * California 281.svg California State Route 281
 * Florida 281.svg Florida State Road 281
 * Georgia 281.svg Georgia State Route 281
 * Iowa 281.svg Iowa Highway 281
 * Elongated circle 281.svg Kentucky Route 281
 * MD Route 281.svg Maryland Route 281
 * MN-281 (1948).svg Minnesota State Highway 281 (former)
 * MT-sec-281.svg Montana Secondary Highway 281 (former)
 * New Mexico 281.svg New Mexico State Route 281
 * NY-281.svg New York State Route 281
 * NC 281.svg North Carolina Highway 281
 * North Dakota 281.svg North Dakota Highway 281
 * OH-281.svg Ohio State Route 281
 * Oklahoma State Highway 281A.svg Oklahoma State Highway 281A
 * OR 281.svg Oregon Route 281
 * PA-281.svg Pennsylvania Route 281
 * South_Carolina_281.svg South Carolina Highway 281
 * Secondary Tennessee 281.svg Tennessee State Route 281
 * Texas 281.svg Texas State Highway 281 (former proposed)
 * Texas Loop 281.svg Texas State Highway Loop 281
 * Texas FM 281.svg Farm to Market Road 281 (Texas)
 * Utah SR 281.svg Utah State Route 281 (former)
 * WA-281.svg Washington State Route 281