List of highways numbered 375

Route 375 or Highway 375 may refer to:

Canada

 * Manitoba Provincial Road 375
 * New Brunswick Route 375
 * Saskatchewan Highway 375

Japan

 * Japanese National Route Sign 0375.svg Japan National Route 375

United States

 * I-375.svg Interstate 375
 * Arkansas 375.svg Arkansas Highway 375
 * Florida 375.svg Florida State Road 375
 * Georgia 375.svg Georgia State Route 375 (former)
 * MD Route 375.svg Maryland Route 375 (unsigned)
 * Nevada 375.svg Nevada State Route 375
 * NY-375.svg New York State Route 375
 * Ellipse sign 375.svg Puerto Rico Highway 375
 * Texas Loop 375.svg Texas State Highway Loop 375
 * Virginia 375.png Virginia State Route 375
 * WY-375.svg Wyoming Highway 375