List of highways numbered 378

The following highways are numbered 378:

Canada

 * Saskatchewan Highway 378

Japan

 * Japanese National Route Sign 0378.svg Japan National Route 378

United States

 * I-378 (PA 1957).svg Interstate 378 (former)
 * US 378.svg U.S. Route 378
 * Georgia 378.svg Georgia State Route 378
 * Louisiana 378.svg Louisiana Highway 378
 * MD Route 378.svg Maryland Route 378 (unsigned)
 * Nevada 378.svg Nevada State Route 378 (former)
 * New Mexico 378.svg New Mexico State Road 378
 * NY-378.svg New York State Route 378
 * OH-378.svg Ohio State Route 378
 * PA-378.svg Pennsylvania Route 378
 * Ellipse sign 378.svg Puerto Rico Highway 378
 * Virginia 378.png Virginia State Route 378