List of highways numbered 380

Route 380 or Highway 380 may refer to:

Canada

 * New Brunswick Route 380
 * Newfoundland and Labrador Route 380

Japan

 * Japanese National Route Sign 0380.svg Japan National Route 380

United States

 * I-380.svg Interstate 380
 * US 380.svg U.S. Route 380
 * Arizona 380.svg Arizona State Route 380 (cancelled proposal)
 * Arkansas 380.svg Arkansas Highway 380
 * Georgia 380.svg Georgia State Route 380
 * Louisiana 380.svg Louisiana Highway 380
 * MD Route 380.svg Maryland Route 380
 * NY-380.svg New York State Route 380 (former)
 * OH-380.svg Ohio State Route 380
 * OR 380.svg Oregon Route 380
 * PA-380.svg Pennsylvania Route 380
 * Ellipse sign 380.svg Puerto Rico Highway 380
 * Secondary Tennessee 380.svg Tennessee State Route 380