List of highways numbered 580

Route 580, or Highway 580, may refer to:

Canada

 * Alberta Highway 580.svg Alberta Highway 580
 * NB 580.svg New Brunswick Route 580
 * Ontario Highway 580.svg Ontario Highway 580

United Kingdom

 * UK road A580.svg A580 road

United States

 * I-580.svg I-580
 * Interstate 580 (California), a spur connecting the San Francisco Bay Area to the San Joaquin Valley from U.S. Route 101 to Interstate 5
 * Interstate 580 (Nevada), a spur connecting Carson City, Nevada to Reno, Nevada (also signed as U.S. Route 395)
 * Interstate 580 (Nebraska), a former route and now part of U.S. Route 75 in Omaha, Nebraska