List of investigational antipsychotics

This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Monoamine receptor modulators

 * Brilaroxazine (RP5063; oxaripiprazole) – atypical antipsychotic (D2/3/4 and 5-HT1A partial agonist and 5-HT2A/2B/7 antagonist)
 * FKF-02SC (TGOF-02N) – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)
 * Masupirdine (SUVN-502) – 5-HT6 receptor antagonist
 * N-methyl amisulpride (LB-102) – D2,3, 5-HT7, receptor antagonists (methylated version of amisulpride)
 * Ralmitaront (RG-7906, RO-6889450) – TAAR1 agonist
 * Ulotaront (SEP-856, SEP-363856) – 5-HT1A receptor and TAAR1 agonist
 * Usmarapride (SUVN-D4010) – 5-HT4 receptor partial agonist

Glutamate receptor modulators

 * Pomaglumetad methionil (DB-103, LY-2140023, LY-2812223) – mGluR2 and mGluR3 agonist

Acetylcholine receptor modulators

 * Emraclidine (CVL-231) – M4 muscarinic acetylcholine receptor positive allosteric modulator.
 * KarXT (xanomeline/trospium) – combined M1 and M4 muscarinic acetylcholine receptor agonist and peripherally-selective muscarinic acetylcholine receptor antagonist.
 * ML-007 – M1 and M4 muscarinic acetylcholine receptor agonist.
 * NBI-1117568 (HTL 0016878) – M4 muscarinic acetylcholine receptor agonist.

Cannabinoid receptor modulators

 * Cannabidiol (CBD; GW-42003, GWP-42003, GWP-42003-P, ECP-012A; Arvisol, Epidiolex) – cannabinoid receptor modulator, antioxidant, other actions

Other/mixed receptor modulators

 * CVN766 – Orexin receptor type 1 antagonist
 * Deudextromethorphan (d-DM; AVP-786, CTP-786) – σ1 receptor agonist, serotonin–norepinephrine reuptake inhibitor, uncompetitive NMDA receptor antagonist, muscarinic acetylcholine receptor agonist, other actions
 * Roluperidone (CYR-101, MIN-101, MT-210) – 5-HT2A and σ2 receptor antagonist
 * TAK-041 (NBI 1065846) – GPR139 receptor agonist

Enzyme inhibitors

 * Luvadaxistat (NBI 1065844, TAK-831) – D-amino acid oxidase inhibitor.
 * MK-8189 – phosphodiesterase 10A inhibitor.
 * Osoresnontrine (BI-409306, SUB-166499) – phosphodiesterase 9A inhibitor
 * Sodium benzoate (SND-11, SND-12, SND-13, SND-14; Clozaben, NaBen) – D -amino acid oxidase inhibitor

Ion channel modulators

 * Evenamide (NW-3509; NW-3509A) – Nav1.3, Nav1.7, and Nav1.8 voltage-gated sodium channel blocker

Others

 * TS-134 (TS-1341) – undefined mechanism of action
 * Kratom – Has shown antipsychotic-like effects on par with haloperidol