List of mayors of the 50 largest cities in Spain

This is a list of mayors of the 50 largest cities in Spain, are ordered the estimated populations as of 2022. These 50 cities have a combined population of 17.5 million, or 37% of the national population.

The breakdown of mayoral political parties is 30 from the People's Party, 14 from the Spanish Socialist Workers' Party, and 6 from local or regional political parties.