List of notable disease outbreaks in the United States

This is a list of notable disease outbreaks in the United States:

1700s

 * 1775–1782 North American smallpox epidemic
 * 1789–1790 influenza epidemic
 * 1793 Philadelphia yellow fever epidemic

1800s

 * 1837 Great Plains smallpox epidemic
 * 1849-1850 Tennessee cholera epidemic
 * 1853 yellow fever epidemic
 * 1862 Pacific Northwest smallpox epidemic
 * 1878 Lower Mississippi Valley yellow fever epidemic

1900s

 * 1900–1904 San Francisco plague epidemic
 * 1916 New York City polio epidemic
 * 1918–1930 Encephalitis lethargica epidemic
 * 1924 Los Angeles pneumonic plague outbreak
 * 1924–1925 Minnesota smallpox epidemic
 * 1947 New York City smallpox outbreak
 * 1962-1965 rubella epidemic
 * 1976 Philadelphia Legionnaires' disease outbreak
 * 1976 swine flu outbreak
 * 1987 Carroll County cryptosporidiosis outbreak
 * 1990–1991 Philadelphia measles outbreak
 * 1993 Four Corners hantavirus outbreak
 * 1992–1993 Jack in the Box E. coli outbreak
 * 1993 Milwaukee cryptosporidiosis outbreak
 * 1996 Odwalla E. coli outbreak

2000s

 * 2003 Midwest monkeypox outbreak
 * 2006 North American E. coli O157:H7 outbreak in spinach
 * 2006 North American E. coli O157:H7 outbreaks
 * 2008 United States salmonellosis outbreak
 * 2009 swine flu pandemic in the United States
 * 2011 United States listeriosis outbreak
 * 2012 outbreak of Salmonella
 * 2012–2013 flu season
 * 2014 enterovirus D68 outbreak
 * 2015 Bronx Legionnaires' disease outbreaks
 * 2015 United States E. coli outbreak
 * 2015 United States H5N2 outbreak
 * 2016 United States Elizabethkingia outbreak
 * 2017–2018 United States flu season
 * 2018 United States adenovirus outbreak
 * 2019 New York measles outbreak
 * 2019 Pacific Northwest measles outbreak
 * 2019 United States hepatitis A outbreak
 * 2019–2020 United States flu season
 * 2022–2023 mpox outbreak in New York (state)
 * 2022–2023 United States P. aeruginosa outbreak in eye drops