List of number-one songs of 2023 (Panama)

This is a list of the number-one songs of 2023 in Panama. The charts are published by Monitor Latino, based on airplay across radio stations in Panama using the Radio Tracking Data, LLC in real time, with its chart week running from Monday to Sunday.

In 2023 so far, twelve songs reached number one in Panama, with eight of them being collaborations; a thirteenth single (which was also a collaboration), "Quevedo: Bzrp Music Sessions, Vol. 52" by Bizarrap and Quevedo began its run at number one in October 2022. In fact, nineteen acts topped the chart as either lead or featured artists with eleven—Marc Anthony, Anuel AA, Eladio Carrión, Farah, Mora, Saiko, La Factoría, Farruko, Boza, Emilia and Tini—achieving their first number-one single in Panama.

Bizarrap is the second act after Karol G to replace himself at number one in Panama, as his collaboration with Shakira, "Bzrp Music Sessions, Vol. 53" (which debuted at number one) knocked off his collaboration with Quevedo, "Bzrp Music Sessions, Vol. 52". Maluma became the third act to replace himself at number one, as his collaboration with Anuel AA, "Diablo, Que Chimba" (which debuted at number one and extended Maluma's record as the artist with most number-one debuts in Panama) knocked off his collaboration with Marc Anthony, "La Fórmula".

Maluma is the only act to have more than a number-one song in 2023, with three.