List of people from Key West, Florida


 * Vic Albury (1947–2017), Major League Baseball pitcher
 * Bronson Arroyo (born 1977), MLB baseball player
 * John James Audubon (1785–1851), naturalist, painter, ornithologist
 * Elizabeth Bishop (1911–1979), poet, short-story writer
 * Jimmy Buffett (1946–2023), singer-songwriter, musician, author, actor, businessman
 * Truman Capote (1924–1984), novelist, screenwriter, playwright, actor
 * Eric Carle (1929–2021), children's book author and illustrator most famous for The Very Hungry Caterpillar
 * David Allan Coe (born 1939), musician
 * Tom Corcoran (1943–2023), author
 * Sandy Cornish (1793–1869), farmer, businessperson, civic leader, former slave
 * Paul Cotton (1943–2021), musician
 * John Dewey (1859–1952), philosopher, educational reformer, psychologist
 * John Dos Passos (1896–1970), novelist
 * Stepin Fetchit (1902–1985), vaudevillian, comedian, film actor
 * Mel Fisher (1922–1998), treasure hunter, best known for finding the 1622 wreck of the Nuestra Señora de Atocha
 * Robert Fuller (born 1933), actor
 * Khalil Greene (born 1979), MLB shortstop
 * Ernest Hemingway (1899–1961), novelist, short-story writer, journalist, sportsman
 * Winslow Homer (1836–1910), landscape painter, printmaker
 * Mike Leach (1961–2022), college football coach
 * Alison Lurie (1926–2020), Pulitzer Prize-winning novelist, academic
 * Stephen Mallory (1812–1873), U.S. senator
 * James Merrill (1926–1995), Pulitzer Prize-winning poet
 * George Mira (born 1942), football player
 * Diana Nyad (born 1949), author, journalist, motivational speaker, long-distance swimmer; famous for being the first person to swim from Cuba to Key West without the aid of a shark cage
 * Bettie Page (1923–2008), pin-up model
 * John Patterson (born 1967), MLB second baseman
 * Quincy Perkins (born 1980), filmmaker
 * Boog Powell (born 1941), baseball player
 * David Robinson (born 1965), basketball player
 * Thomas Sanchez (born 1943), author
 * Shel Silverstein (1930–1999), author, cartoonist and musician
 * Shane Spencer (born 1972), MLB outfielder
 * Randy Sterling (born 1951), MLB pitcher
 * Wallace Stevens (1879–1955), Pulitzer Prize-winning poet
 * Keith Strickland (born 1953), musician, songwriter, founding member of The B-52s
 * Michel Tremblay (born 1942), Canadian playwright
 * Harry S. Truman (1884–1972), U.S. president
 * Blake R. Van Leer (1893–1956), fifth president of Georgia Institute of Technology, colonel, inventor
 * Dick Vermeil (born 1936), former Super Bowl Champion NFL Coach
 * Tony White (born 1979), defensive coordinator for the Nebraska Cornhuskers
 * Tennessee Williams (1911–1983), author
 * David Wolkowsky (1919–2018), real estate developer, preservationist
 * Stuart Woods (1938–2022), novelist