List of people from Mississippi

This list contains people who were born or lived in the U.S. state of Mississippi.

Activists and advocates

 * Ruby Bridges (born 1954), first African-American child to attend an all-white school in the South (Tylertown)
 * Will D. Campbell (1924–2013), Baptist minister and activist (Amite County)
 * James Chaney (1943–1964), civil rights activist (Meridian)
 * Vernon Dahmer (1908–1966), civil rights activist (Hattiesburg)
 * Charles Evers (1922–2020), civil rights leader, mayor of Fayette (Decatur)
 * Medgar Evers (1925–1963), civil rights leader (Decatur)
 * Myrlie Evers-Williams (born 1933), civil rights activist, journalist (Vicksburg)
 * C. L. Franklin (1915–1984), Baptist minister, father of Aretha Franklin (Shelby)
 * Lloyd L. Gaines (1911–1939?), challenged segregation at University of Missouri School of Law, disappeared in 1939 (Water Valley)
 * Duncan M. Gray Jr. (1926–2016), Episcopal clergyman, civil rights activist (Canton)
 * Winifred Green (1937–2016), civil rights activist (Jackson)
 * Percy Greene (1897–1977), journalist, activist (Jackson)
 * Lawrence Guyot (1939–2012), civil rights activist (Pass Christian)
 * Fannie Lou Hamer (1917–1977), civil rights, voting rights activist (Ruleville)
 * Winson Hudson (1916–2004), civil rights activist (Harmony)
 * Clyde Kennard (1927–1963), civil rights activist (Hattiesburg)
 * Germany Kent (born 1975), journalist, social activist (Greenville)
 * Edwin King (born 1936), civil rights activist, Tougaloo College chaplain (Jackson)
 * Joyce Ann Ladner (born 1943), civil rights activist and educator (Wayne County)
 * Tommie Mabry (b. 1987), author, and activist for impoverished youth (Jackson)
 * Angela McGlowan (born 1970), Republican political commentator, author, and consulting firm CEO
 * James Meredith (born 1933), first African-American student at the University of Mississippi (Kosciusko)
 * Anne Moody (1940–2015), civil rights activist, author (Centreville)
 * Ida B. Wells-Barnett (1862–1931), civil rights activist, women's rights activist (Holly Springs)

Actors and actresses

 * Mary Alice (1941 - 2022), actress (Indianola)
 * Dana Andrews (1909–1992), actor (Covington County)
 * Fred Armisen (born 1966), actor, comedian, and musician (Hattiesburg)
 * Roscoe Ates (1895–1962), actor and musician (Grange)
 * Katherine Bailess (born 1980), film and television actress (Vicksburg)
 * Laura Bailey (born 1981), voice actress (Biloxi)
 * Earl W. Bascom (1906–1995), actor (Columbia)
 * Willie Best (1916–1962), television and film actor (Sunflower)
 * Jimmy Boyd (1939–2009), singer and actor (McComb)
 * Don Briscoe (1940–2004), soap opera actor (Yalobusha County)
 * Geneva Carr (born 1971), television and stage actress (Jackson)
 * Finn Carter (born 1960), actress (Greenville)
 * Wally Cassell (1912–2015), film and television actor
 * Lacey Chabert (born 1982), film and television actress (Purvis)
 * Alvin Childress (1907–1986), actor (Meridian)
 * Gary Collins (1938–2012), film and television actor (Biloxi)
 * Wyatt Emory Cooper (1927–1978), Broadway actor (Quitman)
 * Cassi Davis (born 1964) (Holly Springs)
 * John Dye (1963–2011), film and television actor (Amory)
 * Mary Elizabeth Ellis (born 1979), television and film actress (Laurel)
 * J. D. Evermore (born 1968), film and television actor (Greenville)
 * Ruth Ford (1911–2009), stage and film actress (Brookhaven)
 * Morgan Freeman (born 1937), Academy Award-winning actor (Charleston)
 * M. C. Gainey (born 1948), film and television actor (Jackson)
 * Cynthia Geary (born 1965), actress (Jackson)
 * Gavin Gordon (1901–1983), film, television, and radio actor (Chicora)
 * Allie Grant (born 1994), actress (Tupelo)
 * Gary Grubbs (born 1949) (Amory)
 * Lynn Hamilton (born 1930), actress (Yazoo City)
 * Beth Henley (born 1952), playwright and actress (Jackson)
 * Jim Henson (1936–1990), creator of The Muppets (Greenville)
 * Anthony Herrera (1944–2011) (Wiggins)
 * Wilbur Higby (1867–1934), silent film actor (Meridian)
 * Shauntay Hinton (born 1979), actress and Miss USA 2002 (Starkville)
 * Eddie Hodges (born 1947), child actor (Hattiesburg)
 * Olivia Holt (born 1997), actress (Nesbit)
 * Thelma Houston (born 1943), actress (Leland)
 * James Earl Jones (born 1931), actor (Arkabutla)
 * Robert Earl Jones (1910–2006), actor (Senatobia)
 * Germany Kent (born 1975), actress (Greenville)
 * Simbi Khali (born 1971) (Jackson)
 * Diane Ladd (born 1935), actress (Meridian)
 * Daniel Curtis Lee (born 1991) (Clinton)
 * Tom Lester (1938–2020) (Jackson)
 * Martha Mattox (1879–1933), silent film actor (Natchez)
 * Shane McRae (born 1977) (Starkville)
 * Gerald McRaney (born 1947), actor (Collins)
 * RJ Mitte (born 1992), Breaking Bad actor (Jackson)
 * Gil Peterson (born 1936), actor (Winona)
 * Evelyn Preer (1896–1932) (Vicksburg)
 * Thalmus Rasulala (1939–1991), actor (Arkabutla)
 * Beah Richards (1920–2000), stage, screen and television actress (Vicksburg)
 * Eric Roberts (born 1956), actor (Biloxi)
 * Toni Seawright (born 1964), actress (Pascagoula)
 * Larry Semon (1889–1928), silent film actor, director, producer (West Point)
 * Jamie Lynn Spears (born 1991), actress, singer (McComb)
 * Taylor Spreitler (born 1993), actress, model (Hattiesburg)
 * Stella Stevens (1938–2023), actress (Yazoo City)
 * Tonea Stewart (born 1947) (Greenwood)
 * Trinitee Stokes, actress (born 2006) (Jackson)
 * Byron Thames (born 1969), actor (Jackson)
 * Joe M. Turner (born 1969), actor, magician, professional speaker (Brandon)
 * James Michael Tyler (born 1962) (Winona)
 * Brenda Venus (born 1957), actress (Biloxi)
 * Ray Walston (1914–2001), actor (Laurel)
 * Sela Ward (born 1956), actress (Meridian)
 * James Wheaton (1924–2002) (Meridian)
 * Kit Williamson (born 1985), actor (Jackson)
 * Hattie Winston (born 1945), actress (Greenville)

Artists

 * Jere Allen (born 1944), painter (Oxford)
 * James McConnell Anderson (1907–1998), potter and painter (Ocean Springs)
 * Peter Anderson (1901–1984), potter (Ocean Springs)
 * Walter Inglis Anderson (1903–1965), painter (Ocean Springs)
 * Earl W. Bascom (1906–1995), painter, sculptor, "King of the Cowboy Artists" (Columbia)
 * Howard Bingham (1939–2016), photographer (Jackson)
 * Marshall Bouldin III (1923–2012), portrait painter (Clarksdale)
 * Andrew Bucci (1922–2014), painter (Vicksburg)
 * Byron Burford (1920–2011), painter (Greenville)
 * William Dunlap (born 1944), painter (Webster County)
 * Sam Gilliam (born 1933), color field painter (Tupelo)
 * Theora Hamblett (1895–1977), painter (Oxford)
 * Ted Jackson (born 1956), photojournalist (McComb)
 * Chris LeDoux (1948–2005), bronze sculptor (Biloxi)
 * Alex M. Loeb (1918–2015), painter (Meridian)
 * John McCrady (1911–1968), painter, printmaker (Canton)
 * Ed McGowin (born 1938), sculptor, painter (Hattiesburg)
 * Joshua Meador (1911–1965), animator, artist (Greenwood)
 * Fred Mitchell (1923–2013), abstract expressionist painter (Meridian)
 * Ethel Wright Mohamed (1906–1992), folk stitchery artist (Belzoni)
 * George E. Ohr (1857–1918), potter (Biloxi)
 * James Seawright (1936–2022), sculptor (Jackson)
 * J. Kim Sessums, bronze sculptor, painter (Brookhaven)
 * Floyd Shaman (1935–2005), sculptor (Cleveland)
 * Glennray Tutor (born 1950), painter (Oxford)
 * Gary Walters (born 1941), painter (Jackson)
 * James W. Washington Jr. (1908–2000), painter, sculptor (Gloster)
 * Dick Waterman (born 1935), photographer and blues promoter (Oxford)

Broadcast media personalities

 * Paul Gallo (born 1947), radio host (Shaw)
 * Lee Habeeb (born 1961), conservative talk radio producer (Oxford)
 * Iris Kelso (1926–2003), newspaper journalist and television commentator in New Orleans (Philadelphia)
 * Germany Kent (born 1975), media personality, author (Greenville)
 * Angela McGlowan (born 1970), Fox News political commentator (Oxford)
 * Randall Pinkston (born 1950), newscaster (Yazoo County)
 * Robin Roberts (born 1960), newscaster (Pass Christian)
 * Norman Robinson (born 1951), news anchor (Toomsuba)
 * Tavis Smiley (born 1964), talk show host (Gulfport)
 * Shepard Smith (born 1964), Fox News anchor (Holly Springs)
 * Paula White (born 1966), televangelist, author (Tupelo)
 * Oprah Winfrey (born 1954), talk show host (Kosciusko)

Comedians

 * Rod Brasfield (1910–1958) (Smithville)
 * Jerry Clower (1926–1998) (Liberty)
 * Tommy Davidson (born 1963), stand-up comedian, most notable for time on In Living Color (Rolling Fork)
 * Karlous Miller (born 1983), stand-up comedian (Oxford)
 * Tig Notaro (born 1971), stand-up comedian (Jackson)
 * Cardis Cardell Willis (1937–2007), stand-up comedian (Forest)

Educators

 * Thea Bowman (1937–1990), Roman Catholic religious sister, teacher, and scholar (Yazoo County)
 * James Madison Carpenter (1888–1983), folklorist (Prentiss County)
 * Richard Carson (born 1955), professor of economics (Jackson)
 * Joseph Crespino (born 1972), political scientist (Macon)
 * Jesse Dukeminier (1925–2003), professor of law (West Point)
 * William R. Ferris (born 1942), folklorist, chairman of National Endowment for the Humanities (Vicksburg)
 * Charles Betts Galloway (1849–1909), Methodist bishop, editor (Kosciusko)
 * Edgar Godbold (1879–1952), college president (Lincoln County)
 * George W. Grace (1921–2015), linguist (Corinth)
 * William Baskerville Hamilton (1908–1972), historian, born in Jackson, taught public school in Holly Springs and Jackson
 * Robert Khayat (born 1938), chancellor of the University of Mississippi (Moss Point)
 * Rory Lee (born 1949), clergyman, college president (Ridgeland)
 * Mamie Locke (born 1954), political scientist, dean at Hampton University (Brandon)
 * John A. Lomax (1867–1948), folklorist (Goodman)
 * Frances Lucas (born 1957), president of Millsaps College (Jackson)
 * Bernie Machen (born 1944), president of University of Florida (Greenwood)
 * Walter E. Massey (born 1938), physicist, University of Chicago (Hattiesburg)
 * William H. Miller (born 1941), theoretical chemist (Kosciusko)
 * William Muse (born 1939), chancellor at East Carolina University
 * Rod Paige (born 1933), U.S. secretary of education (Monticello)
 * Milburn Price (born 1938), hymnologist, dean of School of Performing Arts, Samford University (Electric Mills)
 * Dan Reneau (born 1940), president of Louisiana Tech University (Woodville)
 * Argile Smith (born 1955), clergyman and educator (Poplarville)
 * Louis Westerfield (1949–1996), law professor, first African-American Dean of the University of Mississippi School of Law (De Kalb)
 * Fannie C. Williams (1882–1980), normal school educator (Biloxi)

Entrepreneurs and business leaders

 * Jim Barksdale (born 1943), president and CEO of Netscape (Jackson)
 * Joseph A. Biedenharn (1866–1952), confectioner, first Coca-Cola bottler (Vicksburg)
 * George W. Bryan (born 1946), Sara Lee executive (West Point)
 * John H. Bryan (1936–2018), Sara Lee executive (West Point)
 * Bill Bynum, credit union founder and philanthropist
 * Cynthia Cooper, WorldCom vice president, whistleblower (Clinton)
 * Bernard "Bernie" Ebbers (1941–2020), founder and CEO of WorldCom, convicted of fraud and conspiracy (Brookhaven)
 * Joshua Green (1869–1975), shipping magnate, banker (Jackson)
 * Toxey Haas (born 1960), founder and CEO of Haas Outdoors, Inc. (West Point)
 * Robert L. Johnson (born 1946), founder of Black Entertainment Television (Hickory)
 * Ken Lewis (born 1947), Bank of America executive (Meridian)
 * Matteo Martinolich (1860–1934), master shipbuilder (DeLisle)
 * Walter E. Massey (born 1938), corporate executive (Hattiesburg)
 * Glenn McCullough (born 1954), chairman and CEO of GLM Associates, LLC (Tupelo)
 * Charles Moorman (born 1953), CEO of Norfolk Southern (Hattiesburg)
 * Clarence Otis Jr. (born 1956), CEO of Darden Restaurants (Vicksburg)
 * Hartley Peavey (born 1941), founder of Peavey Electronics (Meridian)
 * Pig Foot Mary (1870–1929), culinary entrepreneur (Mississippi Delta)
 * Robert Pittman (born 1953), founder of MTV, executive at AOL (Jackson)
 * J. H. Rush (1868–1931), founder of Rush's Infirmary (De Kalb)
 * Fred Smith (born 1944), founder of FedEx (Marks)
 * James Breckenridge Speed (1844–1912), industrial pioneer
 * Antonio Maceo Walker (1909–1994), president, Universal Life Insurance Company (Indianola)
 * Zig Ziglar (1926–2012), motivational speaker, author, salesman (Yazoo City)

Explorers

 * Moncacht-Apé, Native American explorer of the Yazoo tribe; in the late 1600s or early 1700s, reported to have made the first recorded round-trip transcontinental journey across North America

Filmmakers

 * Charles Burnett (born 1944), film director and producer (Vicksburg)
 * Jamaa Fanaka (1942–2012), film director (Jackson)
 * John Fortenberry, film and television director (Jackson)
 * Lawrence Gordon (born 1936), film producer, Die Hard (Yazoo City)
 * Jonathan Murray (born 1955), creator of the reality television genre (Gulfport)
 * Patrik-Ian Polk (born 1973), film writer and director (Hattiesburg)
 * Bryan Spears (born 1977), film and television producer (McComb)
 * Tate Taylor (born 1969), film director of The Help and Get On Up (Jackson)
 * Larry A. Thompson (born 1944), television and film producer (Clarksdale)

Jurists and lawyers

 * Rhesa Barksdale (born 1944), federal judge (Jackson)
 * Neal Brooks Biggers Jr. (1935–2023), U.S. district judge (Corinth)
 * William Joel Blass (1917–2012), attorney (Wiggins/Gulfport)
 * Debra M. Brown (born 1963), U.S. district judge (Yazoo City)
 * Gerald Chatham (1906–1956), lawyer, lead prosecutor in the Emmett Till case (Hernando)
 * Bobby DeLaughter (born 1954), prosecutor, judge (Jackson)
 * Jess H. Dickinson (born 1947), associate justice, Supreme Court of Mississippi (Charleston)
 * Boyce Holleman (1924–2003), attorney (Wiggins/Gulfport)
 * Perry Wilbon Howard (1877–1961), assistant U.S. attorney general, Republican leader (Ebenezer)
 * Lucy Somerville Howorth (1895–1997), attorney, judge, state legislator (Greenville)
 * E. Grady Jolly (born 1937), judge of the U.S. Fifth Circuit Court of Appeals (Louisville)
 * W. Allen Pepper Jr. (1941–2012), U.S. district judge (Greenwood)
 * Charles W. Pickering (born 1937), U.S. district judge (Jones County)
 * Thomas Rodney (1744–1811), U.S. territorial judge (Natchez)
 * Richard "Dickie" Scruggs (born 1946), attorney (Pascagoula)
 * Constance Slaughter-Harvey (born 1946), judge and attorney (Forest)
 * Michael B. Thornton (born 1954), judge, U.S. Tax Court (Hattiesburg)
 * Michael Wallace (born 1951), lawyer (Biloxi)
 * James R. Williams (1936–2020), lawyer, U.S. attorney (Columbus)

Military figures

 * William Wirt Adams (1819–1888), brigadier general, CSA (Jackson)
 * Van T. Barfoot (1919–2012), World War II colonel and Medal of Honor recipient (Edinburg)
 * William Barksdale (1821–1863), brigadier general, CSA, died at Gettysburg (Jackson)
 * William Billingsley (1887–1913), ensign, first Navy aviator killed in an airplane crash (Winona)
 * Oliver Bosbyshell (1839–1921), Superintendent of the United States Mint (Vicksburg)
 * Alvin C. Cockrell (1918–1942), second lieutenant, USMC, killed in World War II (Hazelhurst)
 * Fox Conner (1874–1951), major general, U.S. Army, mentor to Dwight Eisenhower (Slate Springs)
 * Nathan Bedford Forrest (1821–1877), general, CSA (Hernando)
 * Jeffery Hammond (born 1978), major general, U.S. Army (Hattiesburg)
 * Randolph M. Holder (1918–1942), USN lieutenant (junior grade) (Jackson)
 * Felix Huston (1800–1857), general, Texas army (Natchez)
 * Samuel Reeves Keesler (1896–1918), Army aviator (Greenwood)
 * Newt Knight (1837–1922), Unionist leader (Jones County)
 * Roy Joseph Marchand (1920–1942), World War II fireman first class (Crandall)
 * Henry Pinckney McCain (1861–1941), adjutant general, US Army (Carroll County)
 * John S. McCain Sr. (1884–1945), USN admiral (Teoc)
 * Donald H. Peterson (1933–2018), USAF colonel and NASA astronaut (Winona)
 * Charles Read (1840–1890), naval officer (Meridian)
 * Viola B. Sanders (1921–2013), USN captain, director of women, U.S. Navy (Sidon)
 * Daniel Isom Sultan (1885–1947), inspector general, U.S. Army (Oxford)
 * James Monroe Trotter (1842–1892), first man of color to achieve rank of 2nd Lieutenant, U.S. Army, music historian (Gulfport)
 * Richard H. Truly (born 1937), USN vice-admiral, astronaut, NASA administrator (Fayette)
 * Louis H. Wilson Jr. (1920–2005), Commandant of the Marine Corps and Medal of Honor recipient (Brandon)

Models/pageant winners

 * Jennifer Adcock (born 1980), Miss Mississippi 2002 and Miss Mississippi USA 2005 (Hattiesburg)
 * Kristi Addis (born 1971), Miss Teen USA 1987 (Holcomb)
 * Susan Akin (born 1965), Miss Mississippi 1985 and Miss America 1986 (Meridian)
 * Asya Branch (born 1998), Miss Mississippi 2018, Miss Mississippi USA 2019, and Miss USA 2020 (Booneville)
 * Jenna Edwards (born 1981), former Miss Florida and Miss Florida USA (Brandon)
 * Ruth Ford (1911–2009), model (Hazlehurst)
 * Taryn Foshee (born 1985), Miss Mississippi 2006 (Clinton)
 * Tess Holliday (born 1985), first plus-size model (Laurel)
 * Lauren Jones (born 1982), model, Barker's Beauty on The Price is Right, shoe line namesake (Jackson)
 * June Juanico (born 1938), beauty queen known for dating Elvis Presley in 1955 and 1956 (Biloxi)
 * Nan Kelley (born c. 1965), Miss Mississippi 1985 and GAC's Top 20 Country Countdown hostess (Hattiesburg)
 * Kendra King, Miss Mississippi USA 2006 (Monticello)
 * Christine Kozlowski (born 1988), Miss Mississippi 2008 (D'Iberville)
 * Leah Laviano (born 1988), Miss Mississippi USA 2008, and 1st runner up in Miss USA 2008 (Ellisville)
 * Monica Louwerens (born 1973), Miss Mississippi 1995 (Greenville)
 * Lypsinka (born 1955), drag performer and model (Hazlehurst)
 * Lynda Lee Mead (born 1939), Miss America 1960 (Natchez)
 * Mary Ann Mobley (1939–2014), Miss America 1959 (Brandon)
 * Jasmine Murray (born 1991), Miss Mississippi 2014, Season 8 finalist on American Idol (Starkville)
 * Cheryl Prewitt (born 1957), Miss America 1980 (Ackerman)
 * Crystal Renn (born 1986), plus-size model and fashion model (Clinton)
 * Hannah Roberts (born 1993), Miss University of Southern Mississippi 2015 (Mount Olive)
 * Toni Seawright (born 1964), Miss Mississippi 1987; first African-American winner (Pascagoula)
 * Naomi Sims (1948–2009), fashion model and author (Oxford)
 * Ellen Stratton (born 1939), model and Playboy Playmate (Marietta)
 * Amy Wesson (born 1977), fashion model (Tupelo)
 * Cindy Williams (born 1964), journalist and Miss Mississippi USA 1986
 * Jalin Wood (born 1981), Miss Mississippi 2004 and Miss Mississippi USA 2007 (Waynesboro)

Physicians

 * Henry Cloud (born 1956), clinical psychologist (Vicksburg)
 * Thomas F. Frist Sr. (1910–1998), cardiologist, founder of Hospital Corporation of America (Meridian)
 * Arthur Guyton (1919–2003), physiologist, author of Textbook of Medical Physiology (Oxford)
 * James Hardy (1918–2003), surgeon who performed the first successful cadaveric lung transplant (Jackson)
 * T. R. M. Howard (1908–1976), surgeon and activist (Mound Bayou)
 * Edgar Hull (1904–1984), co-founder of Medical Center of Louisiana at New Orleans and Louisiana State University Health Sciences Center Shreveport (Pascagoula)
 * Thomas Naum James (1925–2010), cardiologist (Amory)

Politicians

 * Thomas Abernethy (1903–1998), U.S. representative (Eupora)
 * Robert H. Adams (1792–1830), U.S. senator (Natchez)
 * James L. Alcorn (1816–1894), governor, U.S. senator (Friars Point)
 * William Allain (1928–2013), governor (Washington)
 * John Mills Allen (1846–1917), U.S. representative (Tishomingo County)
 * Apuckshunubbee (c. 1740–1824), Choctaw chief
 * Haley Barbour (born 1947), governor (Yazoo City)
 * Ethelbert Barksdale (1824–1893), U.S. representative, Confederate congressman (Jackson)
 * William Barksdale (1821–1863), U.S. congressman (Jackson)
 * Ross Barnett (1898–1987), governor (Standing Pine)
 * Cheri Barry (born c. 1955), mayor (Meridian)
 * Marion Barry (1936–2014), Washington, D.C. mayor (Itta Bena)
 * Theodore G. Bilbo (1877–1947), governor and U.S. senator (Poplarville)
 * Marsha Blackburn (born 1952), U.S. representative from Tennessee (Laurel)
 * Hale Boggs (1914–1972), U.S. representative from Louisiana, House majority leader (Long Beach)
 * Mary Booze (1877–1948), first African-American woman to sit on the Republican National Committee (Mound Bayou)
 * David R. Bowen (born 1932), U.S. representative (Houston)
 * Walker Brooke (1813–1869), U.S. senator (Vicksburg)
 * Blanche Bruce (1841–1898), U.S. senator
 * Ezekiel S. Candler Jr. (1862–1944), U.S. representative (Corinth)
 * Joseph W. Chalmers (1806–1853), U.S. senator (Holly Springs)
 * Travis W. Childers (born 1958), U.S. representative (Booneville)
 * John Claiborne (1809–1884), U.S. representative (Natchez)
 * Bryant Clark (born 1975), state representative, son of Robert G. Clark Jr. (Jackson)
 * Robert G. Clark Jr. (born 1928), state representative, speaker pro tempore (Ebenezer)
 * Oliver Clifton (1847–1905), governor (Jackson)
 * Thad Cochran (1937–2019), U.S. senator (Pontotoc)
 * James P. Coleman (1914–1991), governor (Ackerman)
 * Jacqueline Y. Collins (born 1949), Illinois state senator (McComb)
 * Ross A. Collins (1880–1968), U.S. representative (Collinsville)
 * William M. Colmer (1890–1980), U.S. representative (Moss Point)
 * Greg Davis (born 1966), mayor (Southaven)
 * Jefferson Davis (1808–1889), U.S. senator and president of the Confederate States (Warren County)
 * Oliver E. Diaz Jr. (born 1960), former Presiding Justice of the Supreme Court of Mississippi (Mississippi)
 * Wayne Dowdy (born 1943), chairman of the Mississippi Democratic Party (Magnolia)
 * Brad Dye (1933–2018), lieutenant governor (Charleston)
 * James Eastland (1904–1986), U.S. senator (Sunflower)
 * Ronnie Edwards (1952–2016), Louisiana state representative (Woodville)
 * Mike Espy (born 1953), U.S. secretary of agriculture (Yazoo City)
 * Robert C. Farrell (born 1936), Los Angeles city councilman (Natchez)
 * Erik R. Fleming (born 1965), state representative (Clinton)
 * Mary E. Flowers (born 1951), Illinois state representative (Inverness)
 * Tim Ford (1951–2015), speaker of Mississippi House of Representatives (Tupelo)
 * Kirk Fordice (1934–2004), governor (Vicksburg)
 * Webb Franklin (born 1941), U.S. representative (Greenwood)
 * Evelyn Gandy (1920–2007), lieutenant governor (Hattiesburg
 * James Z. George (1826–1897), U.S. senator (Carrollton)
 * Charles H. Griffin (1926–1989), U.S. representative (Utica)
 * Gregg Harper (born 1956), U.S. representative (Jackson)
 * Pat Harrison (1881–1941), U.S. representative (Crystal Springs)
 * Patrick Henry (1843–1930), U.S. representative (Brandon)
 * Thomas C. Hindman (1828–1868), U.S. representative from Arkansas (Ripley)
 * Jon Hinson (1942–1995), U.S. representative (Tylertown)
 * David Holmes (1769–1832), first Governor of Mississippi
 * Jim Hood (born 1962), Attorney General of Mississippi (New Houlka)
 * Delbert Hosemann (born 1947), Mississippi secretary of state (Vicksburg)
 * Benjamin G. Humphreys (1808–1882), governor (Claiborne County)
 * Benjamin G. Humphreys II (1865–1923), U.S. representative (Claiborne County)
 * William Y. Humphreys (1890–1933), U.S. representative (Greenville)
 * Paul B. Johnson Jr. (1916–1985), governor (Hattiesburg)
 * Paul B. Johnson Sr. (1880–1943), judge/governor (Hattiesburg)
 * Pete Johnson (born 1948), state auditor, co-chair of Delta Regional Authority (Clarksdale)
 * Daryl Jones (born 1955), Florida legislator, attorney (Jackson)
 * Penne Percy Korth (born 1942), diplomat (Hattiesburg
 * L. Q. C. Lamar (1825–1893), U.S. senator and supreme court justice (Oxford)
 * Greenwood LeFlore (1800–1865), Choctaw chief, state senator
 * Mamie Locke (born 1954), Virginia state senator (Brandon)
 * Trent Lott (born 1941), U.S. senator and Senate Majority Leader (Grenada)
 * Chokwe Lumumba (1947–2014), activist, attorney, mayor of Jackson
 * John R. Lynch (1847–1939), first African-American speaker of the Mississippi House, U.S. representative (Natchez)
 * Ray Mabus (born 1948), governor and Secretary of the Navy (Starkville)
 * Lewis McAllister (born 1932), state representative (Meridian)
 * Glenn McCullough (born 1954), mayor of Tupelo (Tupelo)
 * Chris McDaniel (born 1971), state senator (Laurel)
 * Anselm J. McLaurin (1848–1909), governor (Brandon)
 * Hernando Money (1839–1912), U.S. senator (Carrollton)
 * Frank A. Montgomery (1830–1903), state representative and circuit judge (Adams County)
 * Isaiah Montgomery (1847–1924), founder, mayor of (Mound Bayou, Mississippi)
 * Sonny Montgomery (1920–2006), U.S. representative (Meridian)
 * Mike Moore (born 1952), Mississippi attorney general (Pascagoula)
 * Stanford Morse (1926–2002), state senator (Gulfport)
 * Henry L. Muldrow (1837–1905), U.S. representative and First Assistant Secretary of the Interior (Lowndes County)
 * Ronnie Musgrove (born 1956), governor (Tocowa)
 * David Myers (born 1961), politician, state representative (Magee)
 * Spencer Myrick (1918–1991), Louisiana legislator (Simpson County)
 * Edmond F. Noel (1856–1927), governor (Lexington)
 * Joe Nosef (born 1969), attorney, chairman of Mississippi Republican Party (Clarksdale)
 * Alan Nunnelee (1958–2015), state senator (Tupelo)
 * Rod Paige (born 1933), U.S. secretary of education (Monticello)
 * Rubel Phillips (1925–2011), gubernatorial candidate Corinth
 * Chip Pickering (born 1963), U.S. representative (Laurel)
 * Stacey Pickering (born 1968), state auditor (Laurel)
 * John E. Rankin (1882–1960), U.S. representative (Itawamba County)
 * Red Shoes (died 1747), assassinated Choctaw leader
 * Clarke Reed (born 1928), state Republican chairman (Greenville)
 * Jack Reed (1924–2016), Republican gubernatorial nominee in 1987
 * Bill Renick (born 1954), mayor, governor's chief of staff (Ashland)
 * Hiram Rhodes Revels (1827–1901), first African-American U.S. senator (Claiborne County)
 * Carol Schwartz (born 1944), District of Columbia politician (Greenville)
 * Abram M. Scott (1785–1833), governor (Wilkinson County)
 * Ronnie Shows (born 1947), U.S. representative (Moselle)
 * Jim Singleton (born 1931), New Orleans councilman (Hazlehurst)
 * Larkin I. Smith (1944–1989), U.S. representative (Poplarville)
 * Larry Speakes (1939–2014), presidential spokesman (Cleveland)
 * James J. Spelman (1841–1894), journalist, state representative (Madison County)
 * John C. Stennis (1901–1995), U.S. senator (De Kalb)
 * Bill Stone (born 1965), state senator (Ashland)
 * Tom Stuart (1936–2001), mayor of Meridian
 * William V. Sullivan (1857–1918), U.S. representative and senator (Winona)
 * Gene Taylor (born 1953), U.S. representative (Bay St. Louis)
 * Bennie Thompson (born 1948), U.S. representative (Bolton)
 * Jacob Thompson (1810–1885), U.S. representative, secretary of the interior (Oxford)
 * W. H. H. Tison (1822–1882), 39th speaker of the Mississippi House of Representatives (Lee County)
 * Amy Tuck (born 1963), lieutenant governor (Maben)
 * James K. Vardaman (1861–1930), governor, U.S. senator (Yalobusha County)
 * Joseph Warren (born 1952), politician, state representative (Magee)
 * Jamie L. Whitten (1910–1995), U.S. representative (Cascilla)
 * Roger Wicker (born 1951), U.S. senator (Pontotoc)
 * Thomas Hickman Williams (1801–1851), U.S. senator (Pontotoc County)
 * Norris C. Williamson (1874–1949), Louisiana state senator (Benton County)
 * William Arthur Winstead (1904–1995), U.S. representative (Philadelphia)
 * William Winter (1923–2020), governor (Grenada)
 * Seelig Wise (1913–2004), planter, state senator (Clarksdale)
 * Fielding L. Wright (1895–1956), governor (Rolling Fork)

Scientists and inventors

 * Earl W. Bascom (1906–1995), inventor of rodeo equipment (Columbia)
 * Harry A. Cole, inventor of Pine-Sol (Jackson)
 * James A. Ford (1911–1968), archaeologist (Water Valley)
 * Fred Haise (born 1933), engineer, astronaut (Biloxi)
 * Elizabeth Lee Hazen (1885–1975), microbiologist, developer of nystatin (Rich)
 * Martin F. Jue, amateur radio inventor, entrepreneur (Starkville)
 * Ben Montgomery (1819–1877), freedman, farmer, inventor (Davis Bend)
 * Joseph Newman, inventor of the Newman motor (Lucedale)
 * Chester H. Pond (1844–1912), inventor of the electrical self-winding clock
 * Henry Sampson (1934–2020), inventor (Jackson)
 * Roy A. Tucker (born 1951), astronomer (Jackson)

Supercentenarians

 * Moses Hardy (1894–2006), lived 112 years and 335 days (Aberdeen)
 * Bettie Wilson (1890–2006), lived 119 years and 153 days

Writers

 * Ace Atkins (born 1970), novelist (Oxford)
 * Howard Bahr (born 1946), novelist (Jackson)
 * Frederick Barthelme (born 1943), novelist and professor (Hattiesburg)
 * Earl W. Bascom (1906–1995), artist and writer (Columbia)
 * Lerone Bennett Jr. (1928–2018), editor of Ebony magazine (Clarksdale)
 * Douglas A. Blackmon (born 1964), journalist and historian (Leland)
 * Maxwell Bodenheim (1892–1954), poet and novelist (Hermanville)
 * Margaret Hunt Brisbane (1858–1925), poet (Vicksburg)
 * Larry Brown (1951–2004), novelist (Oxford)
 * Jack Butler (born 1944), author (Alligator)
 * Mary Cain (1904–1984), journalist (Pike County)
 * Hodding Carter II (1907–1972), journalist (Greenville)
 * Hodding Carter III (born 1935), journalist (Greenville)
 * Craig Claiborne (1920–2000), food writer (Sunflower)
 * Carl Corley (1919–2016), author (Florence)
 * Cola Barr Craig (1861–1930), author and clubwoman (Jackson)
 * Hubert Creekmore (1907–1966), poet, author (Water Valley)
 * Mart Crowley (1935–2020), playwright (Vicksburg)
 * Borden Deal (1922–1985), novelist and short story writer (Pontotoc)
 * Ben Domenech (born 1981), conservative writer and blogger (Jackson)
 * David Herbert Donald (1920–2009), historian (Goodman)
 * Ellen Douglas (Josephine Haxton) (1921–2012), novelist (Greenville)
 * Eliza Ann Dupuy (c. 1814 – 1880), first woman of Mississippi to earn her living as a writer
 * John T. Edge (born 1962), food writer (Oxford)
 * W. Ralph Eubanks (born 1957), author, journalist (Mount Olive)
 * Woody Evans (born 1971?), technology journalist and short story writer (Hattiesburg)
 * John Faulkner (1901–1963), plain-style writer (Ripley)
 * William Faulkner (1897–1962), Nobel laureate (New Albany)
 * William Clark Falkner (1825–1889), businessman, author (Ripley)
 * Vic Fleming (born 1951), puzzle writer (Jackson)
 * Shelby Foote (1916–2005), historian and novelist (Greenville)
 * Charles Henri Ford (1913–2002), poet, novelist, editor (Brookhaven)
 * Richard Ford (born 1944), Pulitzer Prize-winning novelist and short story writer (Jackson)
 * Lynn Franklin (1922–2005), author, police detective
 * Tom Franklin (born 1963), author (Oxford)
 * Ellen Gilchrist (born 1935), novelist, poet, short story writer (Vicksburg)
 * John Grisham (born 1955), legal thrillers novelist (Southaven)
 * Barry Hannah (1942–2010), novelist and short story writer (Clinton)
 * Charlaine Harris (born 1951), mystery author (Tunica)
 * Thomas Harris (born 1940), author, screenwriter (Rich)
 * Beth Henley (born 1952), playwright and screenwriter (Jackson)
 * Beth Holloway, author and mother of Natalee Holloway (Clinton)
 * M. Carl Holman (1919–1988), author, poet, playwright (Minter City)
 * Alan Huffman, author, journalist (Bolton)
 * Sarah Gibson Humphreys (1830–1907), author, suffragist (Warren County)
 * Greg Iles (born 1960), novelist (Natchez)
 * Germany Kent (born 1975), author, journalist (Greenville)
 * Greg Keyes (born 1963), science fiction and fantasy writer (Meridian)
 * Kiese Laymon (born 1974), novelist, memoirist (Jackson)
 * Muna Lee (1895–1965), author and poet (Raymond)
 * Clinton LeSueur (born 1969), journalist, congressional candidate (Holly Springs)
 * Sam Chu Lin (1939–2006), journalist (Greenville)
 * Della Campbell MacLeod (ca. 1884 – ?), author, journalist (Greenwood)
 * Anne Moody (1940–2015), author, activist (Centreville)
 * Willie Morris (1934–1999), author, editor (Jackson)
 * Jess Mowry (born 1960), writer of books and stories for children and young adults (Starkville)
 * Thomas Naylor (1936–2012), author and economist (Jackson)
 * Lewis Nordan (1939–2012), fiction author (Itta Bena)
 * Steven Ozment (1939–2019), historian (McComb)
 * Walker Percy (1916–1990), author (Greenville)
 * William Alexander Percy (1885–1942), author (Greenville)
 * Thomas Hal Phillips (1922–2007), author, film actor (Corinth)
 * Robert M. Price (born 1954), theologian, writer (Jackson)
 * William Raspberry (1935–2012), public affairs columnist (Okolona)
 * Julia Reed (born 1960), magazine writer, columnist ([Greenville, Mississippi])
 * Kevin Sessums (born 1956), magazine editor (Forest)
 * Donald C. Simmons Jr. (born 1963), author and filmmaker (Eupora)
 * Roscoe Simmons (1881–1951), journalist, activist (Greenville?)
 * Patrick D. Smith (1927–2014), novelist (Mendenhall)
 * Robert Bruce Smith IV (1945–2014), author, local historian (Tupelo)
 * Lynne Spears (born 1955), author (Magnolia)
 * Elizabeth Spencer (1921–2019), novelist (Carrollton)
 * Stuart Stevens, author, political consultant (Jackson)
 * William N. Still Jr. (born 1932), maritime historian (Columbus)
 * Kathryn Stockett (born 1969), novelist (Jackson)
 * Kate Stone (1841–1907), diarist (Mississippi Springs, Hinds County)
 * Donna Tartt (born 1963), novelist (Greenwood)
 * Clifton Taulbert (born 1945), author and speaker (Glen Allan)
 * Mildred Taylor (born 1943), author (Jackson)
 * Wright Thompson (born 1976), sports writer (Clarksdale)
 * Natasha Trethewey (born 1966), 2007 Pulitzer Prize poet (Gulfport)
 * Jamie Langston Turner (born 1949), Christian novelist
 * Irving Vendig (1902–1995), television writer (Holly Springs)
 * Brenda Venus (born 1947), author (Biloxi)
 * Howard Waldrop (born 1946), science fiction author (Houston)
 * Rosa Kershaw Walker (1840–1909), writer, journalist, newspaper editor (Mississippi)
 * Jesmyn Ward (born 1977), novelist (DeLisle)
 * Peggy Webb (born 1942), romance novel author (Mooreville)
 * Eudora Welty (1909–2001), novelist, short story writer (Jackson)
 * Curtis Wilkie (born 1940), journalist, historian (Greenville)
 * Paige Williams (born 1969), journalist, author (Tupelo)
 * Tennessee Williams (1911–1983), playwright (Columbus)
 * Amos N. Wilson (1941–1995), psychologist, author (Hattiesburg)
 * Richard Nathaniel Wright (1908–1960) (Roxie)
 * Al Young (1939–2021), poet, novelist, essayist, screenwriter (Ocean Springs)
 * Stark Young (1881–1963), playwright, novelist, literary critic, essayist (Como)

Other people

 * Arthur Blessitt (born 1940), preacher (Greenville)
 * Miriam Chamani (born 1943), Mambo priestess, co-founder of New Orleans Voodoo Spiritual Temple (Jackson)
 * James Copeland (1823–1857), outlaw and co-leader of Wages and Copeland Clan (Jackson County)
 * Cat Cora (born 1967), first female Iron Chef America in franchise history (Jackson)
 * Margaret Ferguson (born 1968), political scientist (Hattiesburg)
 * Jeff Fort (born 1947), leader of Black P. Stones Nation (Aberdeen)
 * Natalee Holloway (born 1986), unsolved disappearance (Clinton)
 * Larry Hoover (born 1950), leader of Gangster Disciple Nation (Jackson)
 * Abby Howard, internet cartoonist
 * Leslie Hubricht (1908–2005), biologist and malacologist (Meridian)
 * Mary Comfort Leonard (1856–1940), founder of Delta Gamma fraternity (Kosciusko)
 * Floyd Mayweather Sr. (born 1952), boxer (Amory)
 * Kelly Mitchell, leader of Romani people in Mississippi
 * L. H. Musgrove (1832–1868), outlaw hanged by vigilante committee in Denver, Colorado (Panola County)
 * Haller Nutt (1816–1864), planter, builder of Longwood (Jefferson County)
 * Richard Ragan (born 1964), White House official, UN diplomat (Cleveland)
 * The Scott Sisters, convicted of murder in controversial case that drew national attention
 * Lenny Skutnik (born 1953), celebrity rescuer of 1982 disaster victim
 * Toby Turner (born 1985), YouTube star, better known as Tobuscus (Osborn)