List of prime ministers of Guinea-Bissau

This article lists the prime ministers of Guinea-Bissau, since the establishment of the office of prime minister in 1973.

Since Guinea-Bissau's declaration of independence from Portugal on 24 September 1973, there have been twenty-two prime ministers and two acting prime ministers. The current holder of the office is Rui Duarte de Barros, who was appointed by a decree of president Umaro Sissoco Embaló on 21 December 2023.

List of officeholders
{{legend||African Party for the Independence of Guinea and Cape Verde (PAIGC)|border=1px solid #aaa}} {{legend||Party for Social Renewal (PRS)|border=1px solid #AAAAAA}} {{legend||Assembly of the People United (APU)|border=1px solid #aaa}}
 * Political parties

{{legend||Independent|border=1px solid #aaa}}
 * Other factions

{{legend|#E6E6AA|Denotes Acting Prime Minister}}
 * Symbols


 * Symbols

Died in office