List of rampage killers (familicides in the Americas)

This is a list of mass or spree killers in the Americas, excluding the United States that committed a familicide. A mass murderer is typically defined as someone who kills three or more people in one incident, with no "cooling off" period, not including themselves. A mass murder typically occurs in a single location where one or more persons kill several others.

The victims must have been largely the relatives of the perpetrator to be considered a familicide.

This list does not include serial killers, members of democidal governments, or major political figures who orchestrated such actions.

Abbreviations and footnotes
* – Marks cases where all the victims were relatives of the perpetrator

W – A basic description of the weapons used in the murders
 * F – Firearms and other ranged weapons, especially rifles and handguns, but also bows and crossbows, grenade launchers, flamethrowers, or slingshots
 * M – Melee weapons, like knives, swords, spears, machetes, axes, clubs, rods, stones, or bare hands
 * O – Any other weapons, such as bombs, hand grenades, Molotov cocktails, poison and poisonous gas, as well as vehicle and arson attacks
 * A – indicates that an arson attack was the only other weapon used
 * V – indicates that a vehicle was the only other weapon used
 * E – indicates that explosives of any sort were the only other weapon used
 * P – indicates that an anaesthetising or deadly substance of any kind was the only other weapon used (includes poisonous gas)