List of side effects of trimethoprim/sulfamethoxazole

The following list contains adverse effects by incidence of trimethoprim/sulfamethoxazole.

Common (>1% frequency)

 * Fever
 * Nausea
 * Vomiting
 * Diarrhea
 * Weight loss
 * Rash
 * Muscle aches
 * Joint pain
 * Itch
 * Sore mouth
 * Hyperkalaemia (high blood potassium)
 * Thrombocytopenia (low number of platelets in the blood)

Infrequently (0.1–1.0% frequency)

 * Headache
 * Jaundice
 * Elevated liver transaminases
 * Peripheral neuritis
 * Drowsiness
 * Constipation
 * Photosensitivity (light sensitivity)
 * Blood dyscrasias (e.g. neutropaenia)

Rare (<0.1% frequency)

 * Megaloblastic anaemia
 * Methaemoglobinaemia
 * Erythema multiforme
 * Low blood sugar
 * Hepatitis (liver swelling)
 * Crystalluria (crystals in the urine)
 * Urinary obstruction causing difficulty passing urine
 * Lowered mental acuity
 * Depression
 * Tremor
 * Aplastic anaemia
 * Haemolytic anaemia
 * Hyponatraemia
 * Purpura
 * Eosinophilia
 * Agranulocytosis
 * Serum sickness
 * Anaphylaxis
 * Allergic myocarditis
 * Angioedema
 * Drug fever
 * Periarteritis nodosa
 * Hepatic necrosis
 * Pancreatitis
 * Myelosuppression
 * Haemolysis
 * Stevens–Johnson syndrome
 * Drug reaction with eosinophilia and systemic symptoms
 * Toxic epidermal necrolysis
 * Ataxia
 * Clostridium difficile colitis
 * Aseptic meningitis
 * Pseudomembranous colitis
 * Interstitial nephritis
 * Fulminant hepatic necrosis
 * Hypersensitivity of the respiratory tract
 * Sore throat
 * Pallor
 * Arthralgia

Unknown frequency

 * Hallucinations
 * Cough
 * Glossitis
 * Stomatitis
 * Fatigue
 * Insomnia
 * Impaired kidney function
 * Pulmonary infiltration
 * Shortness of breath