List of signaling peptide/protein receptor modulators

This is a list of signaling peptide/protein receptor modulators

AdipoR1

 * Agonists: Peptide: Adiponectin
 * ADP-355
 * ADP-399; Non-peptide: AdipoRon
 * (–)-Arctigenin
 * Arctiin
 * Gramine
 * Matairesinol


 * Antagonists: Peptide: ADP-400

AdipoR2

 * Agonists: Peptide: Adiponectin
 * ADP-355
 * ADP-399; Non-peptide: AdipoRon
 * Deoxyschizandrin
 * Parthenolide
 * Syringing
 * Taxifoliol


 * Antagonists: Peptide: ADP-400

Angiotensin

 * See here instead.

Bradykinin

 * Agonists: Bradykinin
 * Kallidin


 * Antagonists: FR-173657
 * Icatibant
 * LF22-0542

Calcitonin gene-related peptide receptor

 * Agonists: Amylin
 * CGRP
 * Pramlintide


 * Antagonists: Atogepant
 * BI 44370 TA
 * CGRP (8-37)
 * MK-3207
 * Olcegepant
 * Rimegepant
 * SB-268262
 * Telcagepant
 * Ubrogepant


 * Antibodies: Eptinezumab
 * Erenumab
 * Fremanezumab
 * Galcanezumab

CCKA

 * Agonists: Cholecystokinin


 * Antagonists: Amiglumide
 * Asperlicin
 * Devazepide
 * Dexloxiglumide
 * Lintitript
 * Lorglumide
 * Loxiglumide
 * Pranazepide
 * Proglumide
 * Tarazepide
 * Tomoglumide

CCKB

 * Agonists: Cholecystokinin
 * CCK-4
 * Gastrin
 * Pentagastrin (CCK-5)


 * Antagonists: Ceclazepide
 * CI-988 (PD-134308)
 * Itriglumide
 * L-365,360
 * Netazepide
 * Proglumide
 * Spiroglumide

Unsorted

 * Antagonists: Nastorazepide

CRF1

 * Agonists: Cortagine
 * Corticorelin
 * Corticotropin-releasing hormone
 * Sauvagine
 * Stressin I
 * Urocortin


 * Antagonists: Antalarmin
 * Astressin-B
 * CP-154,526
 * Emicerfont
 * Hypericin
 * LWH-234
 * NBI-27914
 * NBI-74788
 * Pexacerfont
 * R-121919
 * TS-041
 * Verucerfont

CRF2

 * Agonists: Corticorelin
 * Corticotropin-releasing hormone
 * Sauvagine
 * Urocortin


 * Antagonists: Astressin-B

Cytokine
See here instead.

Endothelin

 * Agonists: Endothelin 1
 * Endothelin 2
 * Endothelin 3
 * IRL-1620
 * Sarafotoxin


 * Antagonists: A-192621
 * Ambrisentan
 * Aprocitentan
 * Atrasentan
 * Avosentan
 * Bosentan
 * BQ-123
 * BQ-788
 * Clazosentan
 * Darusentan
 * Edonentan
 * Enrasentan
 * Fandosentan
 * Feloprentan
 * Macitentan
 * Nebentan
 * Sitaxentan
 * Sparsentan
 * Tezosentan
 * Zibotentan

GAL1

 * Agonists: Galanin
 * Galanin (1-15)
 * Galanin-like peptide
 * Galmic
 * Galnon
 * NAX 810-2


 * Antagonists: C7
 * Dithiepine-1,1,4,4-tetroxide
 * Galantide (M15)
 * M32
 * M35
 * M40
 * SCH-202596

GAL2

 * Agonists: Galanin
 * Galanin (1-15)
 * Galanin (2-11)
 * Galanin-like peptide
 * Galmic
 * Galnon
 * J18
 * NAX 810-2


 * Antagonists: C7
 * Galantide (M15)
 * M32
 * M35
 * M40
 * M871

GAL3

 * Agonists: Galanin
 * Galanin (1-15)
 * Galmic
 * Galnon


 * Antagonists: C7
 * Galantide (M15)
 * GalR3ant
 * HT-2157
 * M32
 * M35
 * M40
 * SNAP-37889
 * SNAP-398299

Ghrelin/GHS

 * See here instead.

GH

 * See here instead.

GHRH

 * See here instead.

GLP-1

 * Agonists: Albiglutide
 * Beinaglutide
 * Dulaglutide
 * Efpeglenatide
 * Exenatide
 * GLP-1
 * Langlenatide
 * Liraglutide
 * Lixisenatide
 * Oxyntomodulin
 * Pegapamodutide
 * Semaglutide
 * Taspoglutide

GLP-2

 * Agonists: Apraglutide
 * Elsiglutide
 * Glepaglutide
 * GLP-2
 * Teduglutide

Others

 * Propeptides: Preproglucagon
 * Proglucagon

Glucagon

 * Agonists: Dasiglucagon
 * Glucagon
 * Oxyntomodulin


 * Antagonists: Adomeglivant
 * L-168,049
 * LGD-6972


 * Propeptides: Preproglucagon
 * Proglucagon

GnRH

 * See here instead.

Gonadotropin

 * See here instead.

Growth factor

 * See here instead.

Insulin

 * Agonists: Chaetochromin (4548-G05)
 * Insulin-like growth factor 1
 * Insulin-like growth factor 2
 * Insulin
 * Insulin aspart
 * Insulin degludec
 * Insulin detemir
 * Insulin glargine
 * Insulin glulisine
 * Insulin lispro
 * Mecasermin
 * Mecasermin rinfabate


 * Antagonists: BMS-754807
 * S661
 * S961


 * Kinase inhibitors: Linsitinib


 * Antibodies: Xentuzumab (against IGF-1 and IGF-2)

Kisspeptin

 * Agonists: Kisspeptin
 * Kisspeptin-10


 * Antagonists: Kisspeptin-234

Leptin

 * Agonists: Leptin
 * Metreleptin

MCH1

 * Agonists: Melanin-concentrating hormone


 * Antagonists: ATC-0065
 * ATC-0175
 * GW-803430
 * NGD-4715
 * SNAP-7941
 * SNAP-94847

MCH2

 * Agonists: Melanin-concentrating hormone

Melanocortin

 * See here instead.

mTOR

 * Activators: beta-Hydroxy beta-methylbutyric acid
 * Hydroxynorketamine
 * Leucine
 * NV-5138


 * Inhibitors: Rapalogs: Everolimus
 * Ridaforolimus
 * Sirolimus (Rapamycin)
 * Temsirolimus
 * Umirolimus
 * Zotarolimus; ATP-competitive / indirect: Berberine
 * Curcumin
 * Dactolisib
 * EF-24
 * Epigallocatechin gallate
 * HY-124798
 * NV-5440
 * Pterostilbene
 * Quercetin
 * Resveratrol
 * Sapanisertib
 * Torin-1
 * WYE-687
 * XL-388

Neuropeptide FF

 * Agonists: Neuropeptide AF
 * Neuropeptide FF
 * Neuropeptide SF (RFRP-1)
 * Neuropeptide VF (RFRP-3)


 * Antagonists: BIBP-3226
 * RF9

Neuropeptide S

 * Agonists: Neuropeptide S


 * Antagonists: ML-154
 * SHA-68

Y1

 * Agonists: Neuropeptide Y
 * Peptide YY


 * Antagonists: BIBO-3304
 * BIBP-3226
 * BVD-10
 * GR-231118
 * PD-160170

Y2

 * Agonists: 2-Thiouridine 5'-triphosphate
 * Neuropeptide Y
 * Neuropeptide Y (13-36)
 * Peptide YY
 * Peptide YY (3-36)


 * Antagonists: BIIE-0246
 * JNJ-5207787
 * SF-11

Y4

 * Agonists: GR-231118
 * Neuropeptide Y
 * Pancreatic polypeptide
 * Peptide YY


 * Antagonists: UR-AK49

Y5

 * Agonists: BWX-46
 * Neuropeptide Y
 * Peptide YY


 * Antagonists: CGP-71683
 * FMS-586
 * L-152,804
 * Lu AA-33810
 * MK-0557
 * NTNCB
 * Velneperit (S-2367)

NTS1

 * Agonists:
 * Neurotensin
 * Neuromedin N
 * Antagonists:
 * Meclinertant
 * SR-142948

NTS2

 * Agonists:
 * Neurotensin
 * Antagonists:
 * Levocabastine
 * SR-142948

Opioid

 * See here instead.

OX1

 * Agonists: Orexin (A, B)


 * Antagonists: ACT-335827
 * ACT-462206
 * Almorexant
 * Filorexant
 * Lemborexant
 * Nemorexant
 * RTIOX-276
 * SB-334867
 * SB-408124
 * SB-649868
 * Suvorexant
 * TCS-1102

OX2

 * Agonists: Orexin (A, B)
 * SB-668875


 * Antagonists: ACT-335827
 * ACT-462206
 * Almorexant
 * EMPA
 * Filorexant
 * JNJ-10397049
 * Lemborexant
 * MK-1064
 * SB-649868
 * Seltorexant
 * Suvorexant
 * TCS-1102
 * TCS-OX2-29

Oxytocin

 * See here instead.

Prolactin

 * Agonists: Growth hormone
 * Human placental lactogen
 * Placental growth hormone (growth hormone variant)
 * Prolactin
 * S179D-hPRL
 * Somatotropin


 * Antagonists: Δ1–9-G129R-hPRL
 * Δ1–14-G129R-hPRL
 * G120K-hGH
 * G129R-hPRL


 * Prolactin modulators: Prolactin inhibitors: D2 receptor agonists (e.g., bromocriptine, cabergoline); Prolactin releasers: D2 receptor antagonists (e.g., domperidone, metoclopramide, risperidone)
 * Estrogens (e.g., estradiol)
 * Progestogens (e.g., progesterone)

PTH

 * Agonists: Abaloparatide
 * Parathyroid hormone
 * Parathyroid hormone-related protein (PTHrP)
 * Semparatide
 * Teriparatide

Relaxin

 * Agonists: Insulin-like factor 3
 * Relaxin (1, 2, 3)
 * Serelaxin

Somatostatin

 * See here instead.

Tachykinin

 * See here instead.

TRH

 * Agonists: Azetirelin
 * Fertirelin
 * Montirelin
 * Orotirelin
 * Posatirelin
 * Protirelin
 * Rovatirelin
 * Taltirelin
 * TRH (TRF)

TSH

 * Agonists: Thyrotropin alfa
 * TSH (thyrotropin)

Vasopressin

 * See here instead.

VIPR1

 * Agonists: Peptide: Bay 55-9837
 * LBT-3393
 * PACAP
 * VIP

VIPR2

 * Agonists: Peptide: LBT-3627
 * PACAP
 * VIP

PAC1

 * Agonists: PACAP
 * PACAP (1-27)
 * PACAP (1-38)


 * Antagonists: PACAP (6-38)

Unsorted

 * PHI
 * PHM
 * PHV

Others

 * Endogenous: Adrenomedullin
 * Apelin
 * Asprosin
 * Bombesin
 * Calcitonin
 * Carnosine
 * CART
 * CLIP
 * DSIP
 * Enteroglucagon
 * Formyl peptide
 * GALP
 * GIP
 * GRP
 * Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin)
 * Kininogens
 * Motilin
 * Natriuretic peptides (ANP, BNP, CNP, urodilatin)
 * Nesfatin-1
 * Neuromedin B
 * Neuromedin N
 * Neuromedin S
 * Neuromedin U
 * Obestatin
 * Osteocalcin
 * Resistin
 * Secretin
 * Thymopoietin
 * Thymosins
 * Thymulin
 * Urotensin-II
 * VGF


 * Exogenous: Lifitegrast (LFA-1 antagonist)