List of the oldest buildings in Missouri

This article lists the oldest extant buildings in Missouri, including extant buildings and structures constructed prior to and during the United States rule over Missouri. Only buildings built prior to 1800 are suitable for inclusion on this list, or the building must be the oldest of its type.

In order to qualify for the list, a structure must:
 * be a recognizable building (defined as any human-made structure used or intended for supporting or sheltering any use or continuous occupancy);
 * incorporate features of building work from the claimed date to at least 1.5 m in height and/or be a listed building.

This consciously excludes ruins of limited height, roads and statues. Bridges may be included if they otherwise fulfill the above criteria. Dates for many of the oldest structures have been arrived at by radiocarbon dating or dendrochronology and should be considered approximate. If the exact year of initial construction is estimated, it will be shown as a range of dates.