Little Poison

Little Poison may refer to:


 * Bruce Mather (ice hockey) (1926–1975), an American ice hockey player
 * Jesús Pimentel (born 1940), a Mexican bantamweight boxer
 * Rigoberto Riasco (1953–2022), a Panamanian professional boxer
 * Paul Runyan (1908–2002), American professional golfer
 * Lloyd Waner (1906–1982), Major League Baseball center fielder with the Pittsburgh Pirates
 * Lil Poison, born Victor De Leon III (1998), the youngest professional gamer