Lost Creek (St. Francis River tributary)

Lost Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of the St. Francis River.

The stream headwaters occur at the confluence of the West Fork Lost Creek and East Fork Lost Creek at 37.01806°N, -90.30694°W currently within Lake Wappapello and the confluence with the St. Francis River is at 36.98444°N, -90.33611°W also within Lake Wapapello.

Lost Creek was so named either due to its status as a losing stream or due to a pioneer incident in which a man became lost near its course.