Lou Holtz (disambiguation)

Lou Holtz may refer to:
 * Lou Holtz (born 1937), American football coach
 * His son, Lou Jr. (born 1964), also an American football coach, better known as Skip Holtz
 * His grandson, Lou III (born 1994), an American football player and coach, better known as Trey Holtz
 * Lou Holtz (actor) (1893–1980), an American vaudevillian, comic actor, and theatrical producer
 * His son, Lou Jr., an American screenwriter of The Cable Guy (1996)