Louis Humphreys

Louis Humphreys (September 21, 1816 – May 9, 1880) was a doctor, medical inspector for the Union Army during the American Civil War, and two-term mayor of South Bend, Indiana (1868 - 1872). Abraham Lincoln appointed him as one of eight medical inspectors for the United States Army.

Humphreys was born in Springfield, Ohio. His older brother Harvey was also a doctor. Humphreys came to South Bend in 1844. He attended Indiana Medical College.

He was the second mayor of South Bend. He was a Republican.

Humphreys' father was a native of Ireland who immigrated to the U.S. in his early 20s.

Humphreys was involved in organizing South Bend's original public library.