Luis Castillo

Luis Castillo may refer to:


 * Luis Castillo (American football) (born 1983), Dominican-American NFL defensive end
 * Luis Castillo (second baseman) (born 1975), Dominican Major League Baseball second baseman
 * Luis Castillo (pitcher, born 1992) (born 1992), Dominican Major League Baseball pitcher
 * Luis Castillo (pitcher, born 1995) (born 1995), Dominican Major League Baseball pitcher
 * José Luis Castillo (born 1973), boxer from Mexico
 * Luis Castillo (Ecuadorian boxer), boxer from Ecuador
 * Luis Castillo (musician), keyboard player and backup vocalist for American rock band P.O.D.
 * Luís Leandro Castillo (born 1991), Argentine footballer