Luis Medina

Luis Medina may refer to:


 * Luis Medina (designated hitter) (born 1963), American baseball designated hitter and first baseman
 * Luis Medina (pitcher) (born 1999), Dominican Republic baseball pitcher
 * Luis Medina (athlete) (born 1952), Cuban middle-distance runner
 * Luis Medina (swimmer) (born 1973), Bolivian swimmer
 * Luis Medina Cantalejo (born 1964), Spanish football referee
 * Luis Caicedo Medina (born 1992), Ecuadorian footballer
 * Luis Manuel Medina (1968–2017), Dominican broadcast journalist