Lurtotecan

Lurtotecan is a semi-synthetic analog of camptothecin with antineoplastic activity. Liposomal lurtotecan was in clinical trials as a treatment for topotecan-resistant ovarian cancer, but was discontinued.

Synthesis



 * Heck reaction
 * Mitsunobu reaction
 * Potassium osmate
 * Sharpless asymmetric dihydroxylation
 * Swern oxidation