MAPK1

Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.

Function
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.

Interactions
MAPK1 has been shown to interact with:


 * ADAM17,
 * CIITA,
 * DUSP1,
 * DUSP3,
 * ELK1,
 * FHL2,
 * HDAC4,
 * MAP2K1,
 * MAP3K1
 * MAPK14,
 * MKNK1,
 * MKNK2,
 * Myc,
 * NEK2,
 * PEA15,
 * PTPN7,
 * Phosphatidylethanolamine binding protein 1,
 * RPS6KA1,
 * RPS6KA2,
 * RPS6KA3,
 * SORBS3,
 * STAT5A,
 * TNIP1,
 * TOB1,
 * TSC2,
 * UBR5, and
 * VAV1.

Clinical significance
Mutations in MAPK1 are implicated in many types of cancer.