MCM3

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.

Interactions
MCM3 has been shown to interact with:
 * CDC45-related protein,
 * CDC6,
 * DBF4,
 * MCM2
 * MCM3AP,
 * MCM5,
 * MCM7,
 * ORC4L, and
 * ORC5L.