MCM7

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions
MCM7 has been shown to interact with:


 * CDC45-related protein
 * CDC6,
 * Cell division cycle 7-related protein kinase,
 * DBF4,
 * MCM2,
 * MCM3,
 * MCM4,
 * MCM5,
 * MCM6,
 * MNAT1,
 * ORC1L,
 * ORC2L,
 * ORC3L,
 * ORC5L,
 * Replication protein A1,
 * Retinoblastoma protein, and
 * UBE3A.