MCS

Music

 * Motion City Soundtrack, a pop punk / rock band from Minneapolis, Minnesota

Science and technology

 * Mars Climate Sounder instrument, on Mars Reconnaissance Orbiter spacecraft
 * MAssive Cluster Survey abbreviated as either MACS or MCS
 * Matrix cable system, submarine communications cable connecting Indonesia and Singapore
 * Megawatt Charging System, electric vehicle charging connector
 * Mercalli-Cancani-Sieberg scale, a scale of earthquake intensity, successor to the Mercalli intensity scale
 * Mesoscale convective system, a complex of thunderstorms
 * Modulation and coding scheme, in the telecommunications industry

Biology and medicine

 * Membrane contact site, within cells
 * Minimally conscious state, a disorder of consciousness
 * Multiple chemical sensitivity, an unrecognized and controversial medical diagnosis characterized by chronic symptoms attributed to exposure to low levels of commonly used chemicals
 * Multiple cloning site, the region of restriction enzyme sites in a plasmid

Computing

 * Master of Computer Science
 * Multiple Console Support, in OS/360 and successors
 * Multi categories security, in Security-Enhanced Linux
 * Multinational Character Set, used in VT220 terminals
 * Music Construction Set, a music composition notation program
 * MCS algorithm (Multilevel Coordinate Search), a derivative-free optimization algorithm
 * Micro Computer Set (disambiguation), various Intel microprocessor architectures

Organizations

 * Marcus Corporation (NYSE symbol)
 * Marine Conservation Society, UK
 * Methodist Church in Singapore
 * MCS (fashion brand) (formerly Marlboro Classics), an Italian clothing brand
 * Muslim Council of Scotland

Schools

 * Canada
 * Master's College and Seminary, Peterborough, Ontario
 * Hong Kong
 * Maryknoll Convent School, Kowloon Tong
 * Ireland
 * Malahide Community School, Dublin
 * Philippines
 * Malate Catholic School, Manila
 * Mater Carmeli School, Quezon City, Metro Manila
 * Pakistan
 * Military College of Signals, Rawalpindi, Punjab
 * Murree Christian School, Jhika Gali, Punjab
 * United Kingdom
 * Magdalen College School, Oxford, England
 * Magdalen College School, Brackley, England
 * Michaela Community School, London, England
 * United States
 * Manhattan Country School, New York
 * McMinn County Schools, Tennessee
 * Mellon College of Science, Carnegie Mellon University, Pittsburgh, Pennsylvania
 * Montrose Christian School, Rockville, Maryland
 * Murfreesboro City Schools, Murfreesboro, Tennessee

Other uses

 * Main Character Syndrome another name for people with Narcissism
 * Master of Christian Studies (MCS)
 * A US Navy hull classification symbol: Mine countermeasures support ship (MCS)
 * Management control system
 * Michigan Central Station, a former rail station depot in Detroit, Michigan, US
 * Millennium Cohort Study, UK