MDE

MDE may refer to:

Education

 * Master of Distance Education (MDE), a graduate degree offered by Athabasca University, Canada
 * Michigan Department of Education, a state agency of Michigan, US
 * Minnesota Department of Education, a state agency of Minnesota, US
 * Mississippi Department of Education, a state agency of Mississippi, US

Science

 * Major depressive episode
 * Methylenedioxyethylamphetamine, a psychoactive drug
 * Mid-domain effect spatial/area hypotheses to explain Latitudinal gradients in species diversity
 * Methylenedioxyephedrone also known as MDE

Technology

 * Model-driven engineering, the systematic use of models as primary engineering artifacts
 * Multi-disciplinary Engineering, an extrapolated version of systems engineering
 * In Microsoft Access, mde, the file extension for protected (compiled) databases
 * Microsoft Device Emulator, an emulator for Windows Mobile-based devices
 * Mitsubishi Design Europe, the design studio of Mitsubishi Motors Europe

Other uses

 * Million Dollar Extreme, a comedy sketch group
 * Maximum Downside Exposure, values the maximum downside to the portfolio
 * Markit Document Exchange, platform used by financial market participants for distribution of account onboarding or KYC documents
 * José María Córdova International Airport (IATA code: MDE), an airport in Colombia
 * Major Deegan Expressway in New York City