MDPHP

MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s, which has been reported as a novel designer drug. In the UK its slang name is monkey dust. It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV.

Pharmacology
MDPHP acts as a potent norepinephrine-dopamine reuptake inhibitor. The IC50 values for MDPHP are 0.06 μM at NET, 0.05 μM at DAT and 9 μM at SERT.

Legal status
MDPHP is specifically listed as a controlled substance in Japan and Hungary, and is controlled under analogue provisions in a number of other jurisdictions.

Documented fatalities
A case of a "fatal acute intoxication caused by MDPHP" in a 48 year old male was reported in February 2022 by physicians at an Italian hospital. Another case has been reported, involving a 30-years-old male cocaine consumer, found dead on July 20th, 2023, in Turin; MDPHP and alpha-PHP were the only psychoactive substance found.