ME2

ME2 or ME-2 may refer to:


 * ME2 (gene)
 * "Me²", an episode of the British sitcom Red Dwarf
 * Mass Effect 2, a video game released for Microsoft Windows and Xbox 360 in 2010, and for PlayStation 3 in 2011
 * Maine's 2nd congressional district
 * U.S. Route 2 in Maine
 * Me1 vs Me2 Snooker with Richard Herring
 * Me Two, French film