MED12

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome.

Clinical significance
Mutations in MED12 are responsible for at least two different forms of X-linked dominant mental retardation, Lujan-Fryns syndrome and FG syndrome, as well as instances of prostate cancer.

Mutations in MED12 are associated with uterine leiomyomas and breast fibroepithelial tumors (e.g. fibroadenoma and phyllodes tumors).

Interactions
MED12 has been shown to interact with:


 * Calcitriol receptor,
 * Cyclin-dependent kinase 8
 * Estrogen receptor alpha,
 * Gli3, G9a, PPARGC1A,
 * MED26,
 * SOX9, and
 * Thyroid hormone receptor alpha.