MHC

MHC may refer to:

Biology

 * Major histocompatibility complex, a highly polymorphic region on chromosome 6 with genes particularly involved in immune functions
 * Myosin heavy chain, part of the motor protein myosin's quaternary protein structure

Colleges

 * Mars Hill College (now Mars Hill University), a college in Mars Hill, North Carolina, USA
 * Mount Holyoke College, a college in South Hadley, Massachusetts, USA
 * William E. Macaulay Honors College, an honors college within the City University of New York

Health

 * Managed health care
 * Mental health counselor
 * Metropolitan Hospital Center, East Harlem, New York City

Sports

 * Malaysian Hockey Confederation
 * Mediterranean Handball Confederation
 * Mid Hudson Conference
 * Milwaukee Hurling Club

Other

 * Maimonides Heritage Center
 * Massachusetts Historical Commission
 * Mile high club
 * Mochoʼ language (ISO 639:mhc), a moribund Mayan language spoken in Chiapas, Mexico
 * Mocopulli Airport (IATA: MHC), Dalcahue, Los Lagos, Chile
 * Model of hierarchical complexity
 * Mohawk–Hudson convergence, a meteorological phenomenon
 * Murphy-Hoffman Company
 * Museum of the History of Catalonia
 * A US Navy hull classification symbol: Coastal minehunter (MHC)