MNAT1

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.

Function
Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'ménage à trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM]

Interactions
MNAT1 has been shown to interact with:


 * Cyclin H,
 * Cyclin-dependent kinase 7,
 * Estrogen receptor alpha,
 * MCM7,
 * MTA1,
 * P53, and
 * POU2F1.