MPE

MPE may refer to:
 * Malignant pleural effusion
 * Markov perfect equilibrium, in game theory
 * Max Planck Institute for Extraterrestrial Physics, a German research institute
 * Maximum permissible exposure, the highest power of a light source that is considered safe
 * Mean percentage error, in statistics
 * Media processing engine, short MPE, is an image/video processor
 * Methidiumpropyl-EDTA, a chemical that can intercalate and cleave DNA
 * MIDI Polyphonic Expression, a MIDI specification to provide more expressive qualities for performing music
 * Minimum polynomial extrapolation, a sequence transformation algorithm used for convergence acceleration of vector sequences
 * Miss Philippines Earth
 * Molecular pathological epidemiology, an interdisciplinary integration of molecular pathology and epidemiologylect
 * Mors Principium Est, a Finnish melodic death metal band
 * HP Multi-Programming Executive, a business-oriented minicomputer operating system made by Hewlett-Packard
 * Multiprotocol Encapsulation, a Data link layer protocol
 * Mumbai–Pune Expressway, an Indian motorway
 * Myxopapillary ependymoma, a tumor of the central nervous system
 * Phaswane Mpe (1970–2004), South African author
 * The IATA airport code for the defunct Griswold Airport in Madison, Connecticut
 * The Federal Aviation Administration Location identifier for Philadelphia Municipal Airport, an airport located in Philadelphia, Mississippi
 * .MPE, alternative file extension for .MPG files by Minolta depending on color space