MSPE

MSPE may refer to:
 * Mindful Sport Performance Enhancement: a mental training program for athletes and coaches
 * Mean squared prediction error
 * Mean squared pure error
 * Medical School Performance Evaluation (or dean's letter): a formal, written evaluation of a medical student
 * Mercenaries, Spies and Private Eyes, a role-playing game written by Michael A. Stackpole and published by Flying Buffalo
 * Master of Science, Power Engineering