Main Street Commercial Historic District

Main Street Commercial Historic District or Main Street Commercial District or Main Street Historic Commercial District may refer to:


 * Main Street Commercial District (Dothan, Alabama), a historic district listed on the National Register of Historic Places (NRHP) in Houston County, Alabama
 * Main Street Commercial District (Little Rock, Arkansas), a historic district listed on the NRHP in Pulaski County, Arkansas
 * Main Street Historic Commercial District (Point Arena, California), NRHP-listed in Mendocino County
 * Main Street Commercial District (Georgetown, Kentucky), a historic district listed on the NRHP in Scott County, Kentucky
 * Main Street Historic Commercial District (Georgetown, Kentucky), a boundary increase to that
 * Main Street Commercial Historic District (Kalispell, Montana), listed on the NRHP in Flathead County, Montana
 * Main Street Commercial Historic District (Hamlet, North Carolina), listed on the NRHP in Richmond County, North Carolina
 * Main Street Commercial Historic District (Jefferson, Wisconsin), listed on the NRHP in Jefferson County, Wisconsin
 * Main Street Commercial Historic District (Platteville, Wisconsin), listed on the NRHP in Grant County, Wisconsin
 * Main Street Commercial Historic District (Reedsburg, Wisconsin), listed on the NRHP in Sauk County, Wisconsin
 * Stoughton Main Street Commercial Historic District, Stoughton, Wisconsin, listed on the NRHP in Dane County, Wisconsin
 * Main Street Commercial Historic District (Watertown, Wisconsin), listed on the NRHP in Jefferson County, Wisconsin