Male accessory gland infection

Male accessory gland infection (MAGI) is a condition with signs of inflammation involving one or more sites in the male genital tract. Diagnosis is made according to parameters defined by the World Health Organization, and it is particularly made in relation to infectious or inflammatory causes of male infertility.

Although it is usually caused by infection spreading from the urethra, non-infectious causes also exist.

Definition
Along with testicles (orchitis), MAGI includes infections (bacterial, viral, fungal etc.) involving one or more of the following male genital organs or tracts:
 * epididymis (epididymitis)
 * vas deferens
 * seminal vesicles (seminal vesiculitis)
 * prostate gland (prostatitis)
 * Cowper's glands
 * urethra (urethritis)

Diagnosis
As infection has a negative impact on the secretory function of the accessory glands, findings that could indicate the presence of MAGI include:
 * signs of inflammation in a semen analysis (leukocytes ≥ 1x106/mL and/or elastase ≥ 230 ng/mL)
 * low semen volume
 * elevated semen pH
 * low levels of alpha-glucosidase, fructose and zinc

WHO criteria
MAGI can be diagnosed when there are two or more factors present that meet criteria defined by the World Health Organization (WHO):

Biomarkers
One study has proposed that elevated levels of soluble urokinase-type plasminogen activator receptor (SuPAR) in seminal plasma might be useful as a marker for MAGI.

Causes
The main infectious agents are Enterobacteriaceae (such as Escherichia coli and Klebsiella), Neisseria gonorrhoeae, and Chlamydia trachomatis.

One study has shown that men with MAGI who have lower serum levels of total testosterone tend to have a more complicated form of MAGI, such as involving more than one site, than those with normal levels.

Complications
Potential complications include:
 * obstruction of the epididymis
 * impairment of spermatogenesis
 * impairmentment of sperm function
 * induction of sperm auto-antibodies
 * dysfunctions of the male accessory glands

These complications can result in sexual dysfunction and male subfertility.