Manuel Domínguez

Manuel Dominguez (1803–1882) was a Californian rancher.

Manuel Domínguez may also refer to:


 * Manuel Domínguez (1868–1935), Vice President of Paraguay from 1902 to 1904
 * Manuel Domínguez (early 20th century), Paraguayan writer and member of Viriato Díaz Pérez's 1907 literary circle La Colmena
 * Manuel Jorge Domínguez (born 1962), Spanish cyclist
 * Manuel Domínguez González (born 1974), Spanish politician