Manuel II

Manuel II may refer to:


 * Manuel II of Trebizond (c. 1324–1333), Emperor of Trebizond
 * Manuel II Palaiologos (1350–1425), Byzantine Emperor
 * Patriarch Manuel II of Constantinople, Patriarch of Constantinople from 1244 to 1255
 * Manuel II of Portugal (1889–1932), King of Portugal
 * Manuel II, Patriarch of Lisbon (1888–1977)