Maria Isabel Rodriguez

María Isabel Rodríguez may refer to:


 * María Isabel Rodríguez (government official), former Minister of Health of El Salvador (2009–2014); former Rector of the University of El Salvador (1999–2008)
 * Misa Rodríguez (María Isabel Rodríguez Rivero, born 1999), Spanish football goalkeeper
 * María Isabel (María Isabel López Rodríguez), winner of the Junior Eurovision Song Contest 2004
 * María Isabel Rodríguez Lineros, known as Lucía (born 1964), represented Spain in the 1982 Eurovision Song Contest
 * Maria Isabel Rodriguez, co-author of two novels with André Launay