Mark DeSantis

Mark DeSantis may refer to:


 * Mark DeSantis (businessman) (born 1959), American entrepreneur and political pundit
 * Mark DeSantis (ice hockey) (born 1972), Canadian ice hockey defenceman and coach
 * Marko DeSantis (born 1972), American lead guitarist for rock band Sugarcult
 * Mark DeSantis, professor of finance, see Gunduz Caginalp
 * Mark DeSantis, outside linebacker with the 1976, 1977, and 1978 Michigan Wolverines football teams