Marneral synthase

Marneral synthase is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming). This enzyme catalyses the following chemical reaction


 * (3S)-2,3-epoxy-2,3-dihydrosqualene $$\rightleftharpoons$$ marneral

Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization. This aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of the Iridaceae, originally identified by Dr. Franz-Josef Marner

This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s.