Mary Clarke

Mary Clarke may refer to:
 * Mary Anne Clarke (1776–1852), mistress of Frederick, Duke of York
 * Mary Basset or Mary Clarke (c. 1523–1572), English translator
 * Mary Bassett Clarke (1831–1908), American writer
 * Mary Bayard Devereux Clarke (1827–1886), American writer, poet, and photographer
 * Mary Clarke, birth name of Mary Champion de Crespigny (c. 1749–1812), English novelist and letter writer
 * Mary Clarke (dance critic) (1923–2015), British journalist and dance critic
 * Mary Clarke (letter writer) (?–1705), English gentlewoman and letter writer
 * Mary Clarke Nind (1825–1905), English-born American philanthropist and worker for social justice
 * Mary Cowden Clarke (1809–1898), British author
 * Mary E. Clarke (1924–2011), American military officer
 * Mary Elizabeth Mohl née Clarke (1793–1883), British socialite
 * Mary Ellen Pollard Clarke (1862–1939), American suffragist
 * Mary Frances Clarke (1803–1887), foundress of the Sisters of Charity of the Blessed Virgin Mary
 * Mary H. Gray Clarke (1835–1892), American author, correspondent, and poet
 * Mary Jane Clarke, (1862–1910), British suffragette
 * Mary Pat Clarke (born 1941), American politician
 * Mother Antonia née Mary Clarke (1926–2013), American Catholic nun and activist