Mary Frances

Mary Frances may refer to:
 * Mary Frances Berry (born 1938), American historian, writer, lawyer, activist, and professor
 * Mary Frances Billington (1862–1925), English journalist and writer
 * Mary Frances Clardy (born 1958), American politician
 * Mary Frances Clarke (c. 1802–1887), Irish nun
 * Mary Frances Creighton (1899–1936), American woman convicted and executed for murder
 * Mary Frances Crowley (1906–1990), Irish educator and nurse
 * Mary Frances Dowdall (1876–1939), English writer
 * Mary Frances Early (born 1936), American educator
 * Mary Frances Garrigus (1891–1918), Native American lawyer
 * Mary Frances Gerety (1916–1999), American copywriter
 * Mary Frances Gunner (1894–1953), African American playwright and community leader
 * Mary Frances Heaton (1801–1878), English woman permanently committed to an insane asylum
 * Mary Frances Isom (1865–1920), American librarian
 * Mary Frances Jeffries (1819–1891), English madam and procuror
 * Mary Frances Kennedy Fisher (1908–1992), American food writer
 * Mary Frances Leach (1858–1939), American chemist and professor of chemistry and hygiene
 * Mary Frances Linder Fitzpatrick (1861–1955), American botanist
 * Mary Frances Lovell (1843–1932), British-born American writer, humanitarian, and temperance reformer
 * Mary Frances McCray (1837–1898), American Methodist church leader
 * Mary Frances McDonald (1929–2021), Irish feminist
 * Mary-Frances Monroe (born 1980), American soccer player
 * Mary Frances Overbeck (1878–1955), American potter
 * Mary Frances Penick, birth name of Skeeter Davis (1931–2004), American country music singer and songwriter
 * Mary Frances Reynolds (1932–2016), American actress, singer, and businesswoman
 * Mary Frances Ronalds (1839–1916), American socialite and singer
 * Mary Frances Schervier (1819–1876), German Catholic nun
 * Mary Frances Scott-Siddons (1844–1896), British actress and dramatic reader
 * Mary Frances Thompson, birth name of Te Ata (actress) (1895–1995), Chickasaw actress and storyteller
 * Mary Frances Tucker (1837–1902), American poet
 * Mary Frances Vashon (c. 1818–1854), African American journalist and abolitionist
 * Mary Frances Welch (1924–2021), American teacher and fashion designer
 * Mary Frances Williams (born 1955), American politician
 * Mary Frances Winston Newson (1869–1959), American mathematician
 * Mary Frances Xavier Warde (1810–1884), Irish-born American Roman Catholic nun

Fictional characters

 * Mary-Frances Sumner, in the US primetime TV soap opera Knots Landing, played by Stacy Galina