Mary Osborn (disambiguation)

Mary Osborn or Osborne may refer to:


 * Mary Osborn (born 1940), English cell biologist
 * Mary Jane Osborn (1927–2019), American biochemist and molecular biologist
 * Mary Osborne (1921–1992), American jazz guitarist and guitar manufacturer
 * Mary Pope Osborne (born 1949), American author
 * Mary Osborne, Duchess of Leeds (1723–1764), noblewoman