Matrix metalloproteinase inhibitor

A matrix metalloproteinase inhibitor (INN stem –mastat ) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.

The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis inhibitors.

Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs. Examples include:
 * Batimastat
 * Cipemastat
 * Ilomastat
 * Marimastat
 * Prinomastat
 * Tanomastat

Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria.