Medial pulvinar nucleus

Medial pulvinar nucleus (nucleus pulvinaris medialis) is one of four traditionally anatomically distinguished nuclei of the pulvinar of the thalamus. The other three nuclei of the pulvinar are called lateral, inferior and anterior pulvinar nuclei.

Afferent

 * Medial pulvinar nucleus, together with its lateral and inferior nuclei, receives afferent input from superior colliculus.
 * Medial pulvinar nucleus also receives many afferent inputs from different cortical areas, including cingulate, posterior parietal, premotor and prefrontal cortical areas. This is the pattern of input connections typical for association relay nuclei of the thalamus.

Efferent

 * Medial pulvinar nucleus sends its widespread projections to the different areas of association cortex, including cingulate, posterior parietal, premotor and prefrontal cortical areas. This is the pattern of output connections typical for association relay nuclei of the thalamus.

Functions

 * Medial pulvinar nucleus, together with its lateral and inferior nuclei, is thought to be important for the initiation and compensation of saccadic movements of the eyes. Those nuclei also participate in the visual attention regulation.
 * Medial pulvinar nucleus is also thought to participate in the process of integration and association of information received from different sensory modalities (multisensory or multimodal integration), and also in the process of integration and coordination of sensor input and its corresponding motor response (sensorimotor integration).

Clinical significance
Lesions of the medial pulvinar nucleus can result in neglect syndromes and attentional deficits while preserved connectivity to the medial pulvinar has been implicated in blindsight abilities.