Melpomene (disambiguation)

Melpomene was one of the Nine Muses in Greek mythology and a Greek female given name (popular variant: Melpo).

Melpomene may also refer to:
 * 18 Melpomene, a main belt asteroid
 * Heliconius melpomene, a common butterfly in South and Central America
 * HMS Melpomene, seven ships of the Royal Navy
 * Melpomene (plant), a genus of polypod fern
 * Melpomene (spider) a genus of spider in the family Agelenidae
 * Melpomene Projects, one of the Housing Projects of New Orleans
 * Melpo Mene, an Indie pop band from Stockholm, Sweden
 * Melpomene, a woman reported to have attempted to participate in the 1896 Olympics, possibly Stamata Revithi
 * Melpomene, album from the band Frailty
 * "Melpomene," Book IV of the Histories by Herodotus